Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
FadJ component of anaerobic fatty acid oxidation complexInferred by computational analysisInferred from experiment: fadJ
fatty acid oxidation complex, α componentInferred from experiment: fadB

In Pathway: fatty acid β-oxidation I

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybutyryl-CoA epimerase

Enzyme Commission Synonyms: 3-hydroxybutyryl coenzyme A epimerase, 3-hydroxyacyl-CoA epimerase

A reaction in the β-oxidation cycle, this reaction takes place when particular types of unsaturated fatty acids are degraded.

Citations: [WAKIL55, Stern55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (
i2: 3-cis-dodecenoyl-CoA = trans-dodec-2-enoyl-CoA (

Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ → a 3-oxoacyl-CoA + NADH + H+] (
i1: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Stern55: Stern, J.R., del Campillo, A, Lehninger, A.L. (1955). "Enzymatic racemization of -hydroxybutyryl-S-CoA and the stereospecificity of enzymes of the fatty acid cycle." J. Am. Chem.

WAKIL55: WAKIL SJ (1955). "D(-)beta-Hydroxybutyryl CoA dehydrogenase." Biochim Biophys Acta 18(2);314-5. PMID: 13276396

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC11A.