Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 5.1.2.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.1.2.3

Enzymes and Genes:
FadJ component of anaerobic fatty acid oxidation complex Inferred by computational analysis Inferred from experiment : fadJ
fatty acid oxidation complex, α component Inferred from experiment : fadB

In Pathway: fatty acid β-oxidation I

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybutyryl-CoA epimerase

Enzyme Commission Synonyms: 3-hydroxybutyryl coenzyme A epimerase, 3-hydroxyacyl-CoA epimerase

Summary:
A reaction in the β-oxidation cycle, this reaction takes place when particular types of unsaturated fatty acids are degraded.

Citations: [WAKIL55, Stern55]

Gene-Reaction Schematic: ?

Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (5.3.3.8):
i2: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA (5.3.3.8)

Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ ↔ a 3-oxoacyl-CoA + NADH + H+] (1.1.1.35):
i1: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (1.1.1.211)

Relationship Links: BRENDA:EC:5.1.2.3 , ENZYME:EC:5.1.2.3 , IUBMB-ExplorEnz:EC:5.1.2.3


References

Stern55: Stern, J.R., del Campillo, A, Lehninger, A.L. (1955). "Enzymatic racemization of -hydroxybutyryl-S-CoA and the stereospecificity of enzymes of the fatty acid cycle." J. Am. Chem.

WAKIL55: WAKIL SJ (1955). "D(-)beta-Hydroxybutyryl CoA dehydrogenase." Biochim Biophys Acta 18(2);314-5. PMID: 13276396


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.