Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
FadJ component of anaerobic fatty acid oxidation complex Inferred by computational analysis Inferred from experiment : fadJ
fatty acid oxidation complex, α component Inferred from experiment : fadB

In Pathway: fatty acid β-oxidation I

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybutyryl-CoA epimerase

Enzyme Commission Synonyms: 3-hydroxybutyryl coenzyme A epimerase, 3-hydroxyacyl-CoA epimerase

A reaction in the β-oxidation cycle, this reaction takes place when particular types of unsaturated fatty acids are degraded.

Citations: [WAKIL55, Stern55]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (
i2: 3-cis-dodecenoyl-CoA = trans-dodec-2-enoyl-CoA (

Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ → a 3-oxoacyl-CoA + NADH + H+] (
i1: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Stern55: Stern, J.R., del Campillo, A, Lehninger, A.L. (1955). "Enzymatic racemization of -hydroxybutyryl-S-CoA and the stereospecificity of enzymes of the fatty acid cycle." J. Am. Chem.

WAKIL55: WAKIL SJ (1955). "D(-)beta-Hydroxybutyryl CoA dehydrogenase." Biochim Biophys Acta 18(2);314-5. PMID: 13276396

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, BIOCYC14B.