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Escherichia coli K-12 substr. MG1655 Reaction: 1.1.1.205

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.205

Enzymes and Genes:
IMP dehydrogenase Inferred from experiment : guaB

In Pathway: guanosine ribonucleotides de novo biosynthesis

Supersedes EC number: 1.2.1.14

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: IMP dehydrogenase

Enzyme Commission Synonyms: inosine-5'-phosphate dehydrogenase, inosinic acid dehydrogenase, inosinate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine monophosphate dehydrogenase, IMP oxidoreductase, inosine monophosphate oxidoreductase

Summary:
This is the first reaction unique to GMP biosynthesis.

Enzyme Commission Summary:
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Citations: [MAGASANIK57, TURNER61]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:1.1.1.205 , ENZYME:EC:1.1.1.205 , IUBMB-ExplorEnz:EC:1.1.1.205


References

MAGASANIK57: MAGASANIK B, MOYED HS, GEHRING LB (1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes." J Biol Chem 226(1);339-50. PMID: 13428767

TURNER61: TURNER JF, KING JE (1961). "Inosine 5'-phosphate dehydrogenase of pea seeds." Biochem J 79;147-51. PMID: 13778733


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Apr 18, 2015, biocyc12.