Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
IMP dehydrogenaseInferred from experiment: guaB

In Pathway: guanosine ribonucleotides de novo biosynthesis

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: IMP dehydrogenase

Enzyme Commission Synonyms: inosine-5'-phosphate dehydrogenase, inosinic acid dehydrogenase, inosinate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine monophosphate dehydrogenase, IMP oxidoreductase, inosine monophosphate oxidoreductase

This is the first reaction unique to GMP biosynthesis.

Enzyme Commission Summary:
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Citations: [Magasanik57, Turner61]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Magasanik57: Magasanik B, Moyed HS, Gehring LB (1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes." J Biol Chem 226(1);339-50. PMID: 13428767

Turner61: Turner JF, King JE (1961). "Inosine 5'-phosphate dehydrogenase of pea seeds." Biochem J 79;147-51. PMID: 13778733

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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