Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 1.1.1.205

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.205

Enzymes and Genes:
IMP dehydrogenase Inferred from experiment : guaB

In Pathway: guanosine ribonucleotides de novo biosynthesis

Supersedes EC number: 1.2.1.14

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: IMP dehydrogenase

Enzyme Commission Synonyms: inosine-5'-phosphate dehydrogenase, inosinic acid dehydrogenase, inosinate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine monophosphate dehydrogenase, IMP oxidoreductase, inosine monophosphate oxidoreductase

Summary:
This is the first reaction unique to GMP biosynthesis.

Enzyme Commission Summary:
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Citations: [MAGASANIK57, TURNER61]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.1.1.205 , ENZYME:EC:1.1.1.205 , IUBMB-ExplorEnz:EC:1.1.1.205


References

MAGASANIK57: MAGASANIK B, MOYED HS, GEHRING LB (1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes." J Biol Chem 226(1);339-50. PMID: 13428767

TURNER61: TURNER JF, KING JE (1961). "Inosine 5'-phosphate dehydrogenase of pea seeds." Biochem J 79;147-51. PMID: 13778733


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.