|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: guanosine ribonucleotides de novo biosynthesis
Supersedes EC number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: IMP dehydrogenase
Enzyme Commission Synonyms: inosine-5'-phosphate dehydrogenase, inosinic acid dehydrogenase, inosinate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine monophosphate dehydrogenase, IMP oxidoreductase, inosine monophosphate oxidoreductase
This is the first reaction unique to GMP biosynthesis.
Enzyme Commission Summary:
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
MAGASANIK57: MAGASANIK B, MOYED HS, GEHRING LB (1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes." J Biol Chem 226(1);339-50. PMID: 13428767
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