Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.31

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.31

Enzymes and Genes:
phosphoribosyl-ATP pyrophosphatase Inferred from experiment : hisI

In Pathway: histidine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoribosyl-ATP diphosphatase

Enzyme Commission Synonyms: phosphoribosyl-ATP pyrophosphatase, phosphoribosyladenosine triphosphate pyrophosphatase, 1-(5-phosphoribosyl)-ATP diphosphohydrolase

Summary:
This is the second step in the biosynthesis of histidine

Enzyme Commission Summary:
The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase).

Citations: [Smith65]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.6.1.31 , ENZYME:EC:3.6.1.31 , IUBMB-ExplorEnz:EC:3.6.1.31


References

Smith65: Smith DW, Ames BN (1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis." J Biol Chem 240;3056-63. PMID: 14342333


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC13A.