Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
phosphoribosyl-ATP pyrophosphatase Inferred from experiment : hisI

In Pathway: L-histidine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoribosyl-ATP diphosphatase

Enzyme Commission Synonyms: phosphoribosyl-ATP pyrophosphatase, phosphoribosyladenosine triphosphate pyrophosphatase, 1-(5-phosphoribosyl)-ATP diphosphohydrolase

This is the second step in the biosynthesis of histidine

Enzyme Commission Summary:
The Neurospora crassa enzyme also catalyses the reactions of EC (histidinol dehydrogenase) and EC (phosphoribosyl-AMP cyclohydrolase).

Citations: [Smith65]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Smith65: Smith DW, Ames BN (1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis." J Biol Chem 240;3056-63. PMID: 14342333

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc13.