Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
galactokinaseInferred from experiment: galK

In Pathway: galactose degradation I (Leloir pathway)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: galactokinase

Enzyme Commission Synonyms: galactokinase (phosphorylating), ATP:D-galactose-1-phosphotransferase

Part of galactose, galactoside and glucose catabolism.

Enzyme Commission Summary:
Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-a-D-galactosamine [Yang03a, Timson03, Thoden05].

Citations: [CARDINI53, Neufeld60, Wilkinson49]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


CARDINI53: CARDINI CE, LELOIR LF (1953). "Enzymic phosphorylation of galactosamine and galactose." Arch Biochem Biophys 45(1);55-64. PMID: 13058412

Neufeld60: Neufeld E.F., Feingold D.S., Hassid W.Z. (1960). "Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings." J Biol Chem 235;906-9. PMID: 14426659

Thoden05: Thoden JB, Timson DJ, Reece RJ, Holden HM (2005). "Molecular structure of human galactokinase: implications for type II galactosemia." J Biol Chem 280(10);9662-70. PMID: 15590630

Timson03: Timson DJ, Reece RJ (2003). "Sugar recognition by human galactokinase." BMC Biochem 4;16. PMID: 14596685

Wilkinson49: Wilkinson JF (1949). "The pathway of the adaptive fermentation of galactose by yeast." Biochem J 44(4);460-7. PMID: 16748546

Yang03a: Yang J, Fu X, Jia Q, Shen J, Biggins JB, Jiang J, Zhao J, Schmidt JJ, Wang PG, Thorson JS (2003). "Studies on the substrate specificity of Escherichia coli galactokinase." Org Lett 5(13);2223-6. PMID: 12816414

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.