Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
galactokinase Inferred from experiment : galK

In Pathway: galactose degradation I (Leloir pathway)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: galactokinase

Enzyme Commission Synonyms: galactokinase (phosphorylating), ATP:D-galactose-1-phosphotransferase

Part of galactose, galactoside and glucose catabolism.

Enzyme Commission Summary:
This reaction is different from the one specified by the EC, by having α-D-galactose as a substrate (the official reaction specifies D-galactose). It has been modified since the original literature suggests that the former is the actual substrate for the enzyme .

Citations: [CARDINI53, NEUFELD60, Wilkinson49]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


CARDINI53: CARDINI CE, LELOIR LF (1953). "Enzymic phosphorylation of galactosamine and galactose." Arch Biochem Biophys 45(1);55-64. PMID: 13058412

NEUFELD60: NEUFELD EF, FEINGOLD DS, HASSID WZ (1960). "Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings." J Biol Chem 235;906-9. PMID: 14426659

Wilkinson49: Wilkinson JF (1949). "The pathway of the adaptive fermentation of galactose by yeast." Biochem J 44(4);460-7. PMID: 16748546

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc14.