|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: dihydropyrimidine dehydrogenase (NAD+)
Enzyme Commission Synonyms: dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, dihydrouracil dehydrogenase (NAD+)
Enzyme Commission Summary:
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [Campbell57]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [Schmitt96], Pseudomonas strains [Kim91a, West01] and Escherichia coli [West98, Hidese11].
Hidese11: Hidese R, Mihara H, Kurihara T, Esaki N (2011). "Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil." J Bacteriol 193(4);989-93. PMID: 21169495
Schmitt96: Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD (1996). "Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus." Arch Biochem Biophys 332(1);175-82. PMID: 8806723
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