Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
NAD-dependent dihydropyrimidine dehydrogenaseInferred from experimentInferred by computational analysis: preT, preA

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: dihydropyrimidine dehydrogenase (NAD+)

Enzyme Commission Synonyms: dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, dihydrouracil dehydrogenase (NAD+)

Enzyme Commission Summary:
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [Campbell57]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [Schmitt96], Pseudomonas strains [Kim91a, West01] and Escherichia coli [West98, Hidese11].

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Campbell57: Campbell LL (1957). "Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase." J Biol Chem 227(2);693-700. PMID: 13462991

Hidese11: Hidese R, Mihara H, Kurihara T, Esaki N (2011). "Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil." J Bacteriol 193(4);989-93. PMID: 21169495

Kim91a: Kim S, West TP (1991). "Pyrimidine catabolism in Pseudomonas aeruginosa." FEMS Microbiol Lett 61(2-3);175-9. PMID: 1903745

Schmitt96: Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD (1996). "Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus." Arch Biochem Biophys 332(1);175-82. PMID: 8806723

West01: West TP (2001). "Pyrimidine base catabolism in Pseudomonas putida biotype B." Antonie Van Leeuwenhoek 80(2);163-7. PMID: 11759049

West98: West TP (1998). "Isolation and characterization of an Escherichia coli B mutant strain defective in uracil catabolism." Can J Microbiol 44(11);1106-9. PMID: 10030006

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Nov 30, 2015, biocyc13.