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Escherichia coli K-12 substr. MG1655 Reaction: 2.8.3.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.8.3.10

Enzymes and Genes:
citrate lyase Inferred from experiment : citD , citF , citE

Sub-reaction of:
4.1.3.6: citrate → acetate + oxaloacetate

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: citrate CoA-transferase

Summary:
This is the first reaction in the two-step sequence of citrate lyase. The citryl-ACP intermediate is formed by transfer of ACP from acetyl-ACP.

Enzyme Commission Summary:
The enzyme is a component of EC 4.1.3.6 [citrate (pro-3S)-lyase]. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citrate.

Citations: [Dimroth77]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.8.3.10 , ENZYME:EC:2.8.3.10 , IUBMB-ExplorEnz:EC:2.8.3.10


References

Dimroth77: Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate." Eur J Biochem 80(2);479-88. PMID: 336371


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Jul 4, 2015, biocyc12.