|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
In this reaction the sensor kinase-phosphotransferase BarA is autophosphorylated.
The sensor kinase-phosphotransferase BarA has been shown to autophosphorylate in the presence of ATP. The BarA protein has both a sensor and a response regulator domain. The sensor domain is similar in sequence to the sensor protein EnvZ and the regulator domain is similar to the regulator protein OmpR. In addition, the BarA protein contains a second phospho-donor histidine site in the C-terminal region. By `cross-talk' phosphorylation of OmpR, BarA seems to affect ompC and ompF expression. [Nagasawa92, Ishige94, Tsuzuki95]
Nagasawa92: Nagasawa S, Tokishita S, Aiba H, Mizuno T (1992). "A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli." Mol Microbiol 1992;6(6);799-807. PMID: 1574005
Tsuzuki95: Tsuzuki M, Ishige K, Mizuno T (1995). "Phosphotransfer circuitry of the putative multi-signal transducer, ArcB, of Escherichia coli: in vitro studies with mutants." Mol Microbiol 1995;18(5);953-62. PMID: 8825099
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