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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

In Pathway: BarA UvrY Two-Component Signal Transduction System

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Summary:
In this reaction the sensor kinase-phosphotransferase BarA is autophosphorylated.

The sensor kinase-phosphotransferase BarA has been shown to autophosphorylate in the presence of ATP. The BarA protein has both a sensor and a response regulator domain. The sensor domain is similar in sequence to the sensor protein EnvZ and the regulator domain is similar to the regulator protein OmpR. In addition, the BarA protein contains a second phospho-donor histidine site in the C-terminal region. By `cross-talk' phosphorylation of OmpR, BarA seems to affect ompC and ompF expression. [Nagasawa92, Ishige94, Tsuzuki95]

Citations: [Pao95, Parkinson92, Stock90, Parkinson93]


References

Ishige94: Ishige K, Nagasawa S, Tokishita S, Mizuno T (1994). "A novel device of bacterial signal transducers." EMBO J 1994;13(21);5195-202. PMID: 7957084

Nagasawa92: Nagasawa S, Tokishita S, Aiba H, Mizuno T (1992). "A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli." Mol Microbiol 1992;6(6);799-807. PMID: 1574005

Pao95: Pao GM, Saier MH (1995). "Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution." J Mol Evol 1995;40(2);136-54. PMID: 7699720

Parkinson92: Parkinson JS, Kofoid EC (1992). "Communication modules in bacterial signaling proteins." Annu Rev Genet 1992;26;71-112. PMID: 1482126

Parkinson93: Parkinson JS (1993). "Signal transduction schemes of bacteria." Cell 1993;73(5);857-71. PMID: 8098993

Stock90: Stock JB, Stock AM, Mottonen JM (1990). "Signal transduction in bacteria." Nature 1990;344(6265);395-400. PMID: 2157156

Tsuzuki95: Tsuzuki M, Ishige K, Mizuno T (1995). "Phosphotransfer circuitry of the putative multi-signal transducer, ArcB, of Escherichia coli: in vitro studies with mutants." Mol Microbiol 1995;18(5);953-62. PMID: 8825099


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc14.