Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
asparagine synthetase B Inferred from experiment : asnB
asparagine synthetase A Inferred from experiment : asnA

Sub-reaction of: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+

In Pathway: L-asparagine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aspartate—ammonia ligase

Enzyme Commission Synonyms: asparagine synthetase, L-asparagine synthetase

This is one of two reactions in E. coli that synthesizes asparagine from aspartate. The other reaction uses glutamine as the preferred nitrogen donor.

Citations: [RAVEL62, Webster55]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


RAVEL62: RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W (1962). "Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression." J Biol Chem 237;2845-9. PMID: 14490631

Webster55: Webster GC, Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems." J Biol Chem 215(1);91-9. PMID: 14392145

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc13.