Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Reaction: 6.3.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.1.1

Enzymes and Genes:
asparagine synthetase B Inferred from experiment : asnB
asparagine synthetase A Inferred from experiment : asnA

Sub-reaction of:
6.3.5.4: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+

In Pathway: asparagine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aspartate—ammonia ligase

Enzyme Commission Synonyms: asparagine synθse, L-asparagine synθse

Summary:
This is one of two reactions in E. coli that synthesizes asparagine from aspartate. The other reaction uses glutamine as the preferred nitrogen donor.

Citations: [RAVEL62, WEBSTER55]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:6.3.1.1 , ENZYME:EC:6.3.1.1 , IUBMB-ExplorEnz:EC:6.3.1.1


References

RAVEL62: RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W (1962). "Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression." J Biol Chem 237;2845-9. PMID: 14490631

WEBSTER55: WEBSTER GC, VARNER JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems." J Biol Chem 215(1);91-9. PMID: 14392145


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14B.