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Escherichia coli K-12 substr. MG1655 Reaction: 4.3.2.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.3.2.2

Enzymes and Genes:
adenylosuccinate lyase Inferred from experiment : purB

In Pathway: adenosine ribonucleotides de novo biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenylosuccinate lyase

Enzyme Commission Synonyms: adenylosuccinase, succino AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Summary:
The final step in the de novo biosynthesis of purines, the second of the two step sequence from IMP to AMP.

Enzyme Commission Summary:
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.

Citations: [CARTER56]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:4.3.2.2 , ENZYME:EC:4.3.2.2 , IUBMB-ExplorEnz:EC:4.3.2.2


References

CARTER56: CARTER CE, COHEN LH (1956). "The preparation and properties of adenylosuccinase and adenylosuccinic acid." J Biol Chem 222(1);17-30. PMID: 13366975


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Thu May 28, 2015, BIOCYC14A.