Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 3.6.3.21


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.3.21

Transporters and Genes:
histidine ABC transporterInferred by computational analysis: hisP, hisM, hisQ, hisJ

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: polar-amino-acid-transporting ATPase

Enzyme Commission Synonyms: histidine permease

Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.

Citations: [Kuan95, Saier98, Nikaido97, Walshaw97]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.6.3.21, ENZYME:EC:3.6.3.21, IUBMB-ExplorEnz:EC:3.6.3.21


References

Kuan95: Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases." Res Microbiol 146(4);271-8. PMID: 7569321

Nikaido97: Nikaido K, Liu PQ, Ames GF (1997). "Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity." J Biol Chem 272(44);27745-52. PMID: 9346917

Saier98: Saier MH (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya." Adv Microb Physiol 40;81-136. PMID: 9889977

Walshaw97: Walshaw DL, Lowthorpe S, East A, Poole PS (1997). "Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity." FEBS Lett 414(2);397-401. PMID: 9315727


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc14.