Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
6-phosphofructokinase IInferred from experiment: pfkA
6-phosphofructokinase IIInferred from experiment: pfkB

In Pathway: glycolysis II (from fructose 6-phosphate), glycolysis I (from glucose 6-phosphate)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 6-phosphofructokinase

Enzyme Commission Synonyms: phosphohexokinase, phosphofructokinase I, phosphofructokinase (phosphorylating), 6-phosphofructose 1-kinase, ATP-dependent phosphofructokinase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, nucleotide triphosphate-dependent phosphofructokinase, phospho-1,6-fructokinase, PFK

This is a key control step in glycolysis [Uyeda79]

Enzyme Commission Summary:
D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 6-phosphofructo-2-kinase.

Citations: [Uyeda70, Parmeggiani66, Odeide68, AXELROD52]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


AXELROD52: AXELROD B, SALTMAN P, BANDURSKI RS, BAKER RS (1952). "Phosphonexokinase in higher plants." J Biol Chem 197(1);89-96. PMID: 12981037

Odeide68: Odeide R, Guilloton M, Dupuis B, Ravon D, Rosenberg AJ (1968). "[Study of an enzyme allosteric to 2 substrates: phosphofructokinase of rat muscle. I. Preparation and crystallization of the enzyme]." Bull Soc Chim Biol (Paris) 50(11);2023-33. PMID: 4237772

Parmeggiani66: Parmeggiani A, Luft JH, Love DS, Krebs EG (1966). "Crystallization and properties of rabbit skeletal muscle phosphofructokinase." J Biol Chem 241(20);4625-37. PMID: 4224472

Uyeda70: Uyeda K, Kurooka S (1970). "Crystallization and properties of phosphofructokinase from Clostridium pasteurianum." J Biol Chem 245(13);3315-24. PMID: 4248230

Uyeda79: Uyeda K (1979). "Phosphofructokinase." Adv Enzymol Relat Areas Mol Biol 1979;48;193-244. PMID: 153704

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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