|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 6-phosphofructokinase
Enzyme Commission Synonyms: phosphohexokinase, phosphofructokinase I, phosphofructokinase (phosphorylating), 6-phosphofructose 1-kinase, ATP-dependent phosphofructokinase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, nucleotide triphosphate-dependent phosphofructokinase, phospho-1,6-fructokinase, PFK
This is a key control step in glycolysis [Uyeda79]
Enzyme Commission Summary:
D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 220.127.116.11 6-phosphofructo-2-kinase.
Odeide68: Odeide R, Guilloton M, Dupuis B, Ravon D, Rosenberg AJ (1968). "[Study of an enzyme allosteric to 2 substrates: phosphofructokinase of rat muscle. I. Preparation and crystallization of the enzyme]." Bull Soc Chim Biol (Paris) 50(11);2023-33. PMID: 4237772
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