|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
UMP phosphatase : umpH
pyrimidine nucleotidase : yjjG
broad specificity 5'(3')-nucleotidase and polyphosphatase : umpG
5'-ribonucleotidase : ushA
acid phosphatase / phosphotransferase : aphA
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
AMP + H2O → adenosine + phosphate (126.96.36.199)
IMP + H2O → inosine + phosphate (188.8.131.52)
GMP + H2O → guanosine + phosphate (184.108.40.206)
CMP + H2O → cytidine + phosphate (220.127.116.11/18.104.22.168)
UMP + H2O → uridine + phosphate (22.214.171.124)
Enzyme Commission Primary Name: 5′-nucleotidase
Enzyme Commission Synonyms: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase
This reaction is involved in the hydrolysis of nucleotides.
Enzyme Commission Summary:
Wide specificity for 5-nucleotides.
Instance reaction of [a nucleoside 5'-monophosphate[periplasmic space] + H2O[periplasmic space] → a nucleoside[periplasmic space] + phosphate[periplasmic space]] (no EC#):
i1: a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate (126.96.36.199)
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493