Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.1.3.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.5

Enzymes and Genes:
UMP phosphatase Inferred from experiment : umpH
pyrimidine nucleotidase Inferred from experiment : yjjG
broad specificity 5'(3')-nucleotidase and polyphosphatase Inferred from experiment : umpG
5'-ribonucleotidase Inferred from experiment : ushA
acid phosphatase / phosphotransferase Inferred from experiment : aphA

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reactions:
CMP + H2O → cytidine + phosphate (3.1.3.91)

UMP + H2O → uridine + phosphate (3.1.3.5)

GMP + H2O → guanosine + phosphate (3.1.3.5)

IMP + H2O → inosine + phosphate (3.1.3.5)

AMP + H2O → adenosine + phosphate (3.1.3.5)

Direct generic reaction:
a nucleoside 5'-monophosphate[periplasmic space] + H2O[periplasmic space] → a nucleoside[periplasmic space] + phosphate[periplasmic space] (no EC#)

Enzyme Commission Primary Name: 5′-nucleotidase

Enzyme Commission Synonyms: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase

Summary:
This reaction is involved in the hydrolysis of nucleotides.

Enzyme Commission Summary:
Wide specificity for 5-nucleotides.

Citations: [Gulland38, Heppel51, Segal60]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.3.5 , ENZYME:EC:3.1.3.5 , IUBMB-ExplorEnz:EC:3.1.3.5


References

Gulland38: Gulland JM, Jackson EM (1938). "5-Nucleotidase." Biochem J 32(3);597-601. PMID: 16746659

Heppel51: Heppel LA, Hilmore RJ (1951). "Purification and properties of 5-nucleotidase." J Biol Chem 188(2);665-76. PMID: 14824154

Segal60: Segal HL, Brenner BM (1960). "5'-Nucleotidase of rat liver microsomes." J Biol Chem 235;471-4. PMID: 14444527


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc14.