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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.19


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.1.19

Enzymes and Genes:
nucleoside triphosphate pyrophosphohydrolaseInferred from experiment: mazG

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
dGTP + H2O → dGMP + diphosphate + H+ (3.6.1.19)

dATP + H2O → dAMP + diphosphate + H+ (3.6.1.19)

dUTP + H2O → dUMP + diphosphate + H+ (3.6.1.19/3.6.1.23)

XTP + H2O → XMP + diphosphate + H+ (3.6.1.66)

CTP + H2O → CMP + diphosphate + H+ (3.6.1.19/3.6.1.65)

dITP + H2O → dIMP + diphosphate + H+ (3.6.1.66)

ATP + H2O → AMP + diphosphate + H+ (3.6.1.8)

ITP + H2O → IMP + diphosphate + H+ (3.6.1.19)

dCTP + H2O → dCMP + diphosphate + H+ (3.6.1.12/3.6.1.19/3.6.1.65)

UTP + H2O → UMP + diphosphate + H+ (3.6.1.19)

dTTP + H2O → dTMP + diphosphate + H+ (3.6.1.19)

Enzyme Commission Primary Name: nucleoside-triphosphate diphosphatase

Enzyme Commission Synonyms: nucleoside-triphosphate pyrophosphatase

Enzyme Commission Summary:
May be identical with EC 3.6.1.9 nucleotide diphosphatase.

Citations: [Chern69, Zhang02a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (3.6.1.19):
i1: dGTP + H2O → dGMP + diphosphate + H+ (3.6.1.19)

i2: dATP + H2O → dAMP + diphosphate + H+ (3.6.1.19)

i3: dUTP + H2O → dUMP + diphosphate + H+ (3.6.1.19/3.6.1.23)

i4: XTP + H2O → XMP + diphosphate + H+ (3.6.1.66)

i5: CTP + H2O → CMP + diphosphate + H+ (3.6.1.19/3.6.1.65)

i6: dITP + H2O → dIMP + diphosphate + H+ (3.6.1.66)

i7: ATP + H2O → AMP + diphosphate + H+ (3.6.1.8)

i8: ITP + H2O → IMP + diphosphate + H+ (3.6.1.19)

i9: dCTP + H2O → dCMP + diphosphate + H+ (3.6.1.12/3.6.1.19/3.6.1.65)

i10: UTP + H2O → UMP + diphosphate + H+ (3.6.1.19)

i11: dTTP + H2O → dTMP + diphosphate + H+ (3.6.1.19)

Relationship Links: BRENDA:EC:3.6.1.19, ENZYME:EC:3.6.1.19, IUBMB-ExplorEnz:EC:3.6.1.19


References

Chern69: Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit." J Biol Chem 244(20);5489-95. PMID: 4310599

Zhang02a: Zhang J, Inouye M (2002). "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." J Bacteriol 184(19);5323-9. PMID: 12218018


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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