Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
Xaa-Pro dipeptidaseInferred from experiment: pepQ

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: Xaa-Pro dipeptidase

Enzyme Commission Synonyms: prolidase, imidodipeptidase, proline dipeptidase, peptidase D, γ-peptidase, X-Pro dipeptidase

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

A Mn2+-activated enzyme, in peptidase family M24 (methionyl aminopeptidase family); cytosolic from most animal tissues.

Citations: [DAVIS57, Sjostrom73, Baksi74 , Browne83]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Baksi74: Baksi K, Radhakrishnan AN (1974). "Purification and properties of prolidase (imidodipeptidase) from monkey small intestine." Indian J Biochem Biophys 11(1);7-11. PMID: 4435812

Browne83: Browne P, O'Cuinn G (1983). "The purification and characterization of a proline dipeptidase from guinea pig brain." J Biol Chem 258(10);6147-54. PMID: 6853481

DAVIS57: DAVIS NC, SMITH EL (1957). "Purification and some properties of prolidase of swine kidney." J Biol Chem 224(1);261-75. PMID: 13398404

Sjostrom73: Sjostrom H, Noren O, Josefsson L (1973). "Purification and specificity of pig intestinal prolidase." Biochim Biophys Acta 327(2);457-70. PMID: 4778946

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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