|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 18.104.22.168
In Pathway: acyl carrier protein metabolism
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: [acyl-carrier-protein] phosphodiesterase
Enzyme Commission Synonyms: ACP hydrolyase, ACP phosphodiesterase, AcpH, [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase, holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Enzyme Commission Summary:
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [Thomas05]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [Thomas05]. Activation of apo-ACP to form the holoenzyme is carried out by EC 22.214.171.124, holo-[acyl-carrier-protein] synthase.
Thomas05: Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280(41);34675-83. PMID: 16107329
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