Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Reaction: 3.1.4.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 3.1.4.14

Enzymes and Genes:
acyl carrier protein phosphodiesterase Inferred from experiment : acpH

In Pathway: acyl carrier protein metabolism I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: [acyl-carrier-protein] phosphodiesterase

Enzyme Commission Synonyms: ACP hydrolyase, ACP phosphodiesterase, AcpH, [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase, holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase

Enzyme Commission Summary:
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [Thomas05]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [Thomas05]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase.

Citations: [Vagelos67, Sobhy79]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.4.14 , ENZYME:EC:3.1.4.14 , IUBMB-ExplorEnz:EC:3.1.4.14


References

Sobhy79: Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver." J Biol Chem 254(17);8561-6. PMID: 224058

Thomas05: Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280(41);34675-83. PMID: 16107329

Vagelos67: Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase." J Biol Chem 242(8);1776-81. PMID: 4290442


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14A.