Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:
acyl carrier protein phosphodiesteraseInferred from experiment: acpH

In Pathway: acyl carrier protein metabolism

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: [acyl-carrier-protein] phosphodiesterase

Enzyme Commission Synonyms: ACP hydrolyase, ACP phosphodiesterase, AcpH, [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase, holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase

Enzyme Commission Summary:
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [Thomas05]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [Thomas05]. Activation of apo-ACP to form the holoenzyme is carried out by EC, holo-[acyl-carrier-protein] synthase.

Citations: [Vagelos67, Sobhy79]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Sobhy79: Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver." J Biol Chem 254(17);8561-6. PMID: 224058

Thomas05: Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280(41);34675-83. PMID: 16107329

Vagelos67: Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase." J Biol Chem 242(8);1776-81. PMID: 4290442

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.