|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 18.104.22.168
In Pathway: acyl carrier protein metabolism I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: [acyl-carrier-protein] phosphodiesterase
Enzyme Commission Synonyms: ACP hydrolyase, ACP phosphodiesterase, AcpH, [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase, holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Enzyme Commission Summary:
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [Thomas05]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [Thomas05]. Activation of apo-ACP to form the holoenzyme is carried out by EC 22.214.171.124, holo-[acyl-carrier-protein] synthase.
Thomas05: Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280(41);34675-83. PMID: 16107329
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