Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 1.8.4.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.8.4.8

Enzymes and Genes:
3'-phospho-adenylylsulfate reductase Inferred from experiment : cysH

In Pathway: sulfate reduction I (assimilatory)

Supersedes EC number: 1.8.99.4

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoadenylyl-sulfate reductase (thioredoxin)

Enzyme Commission Synonyms: PAPS reductase, thioredoxin-dependent, PAPS reductase, thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase, 3'-phosphoadenylylsulfate reductase, thioredoxin:3'-phospho-adenylylsulfate reductase, phosphoadenosine-phosphosulfate reductase, adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)

Summary:
The third reaction in converting sulfate to sulfide. The first reaction in the reduction of sulfate to sulfite in the pathway leading to cysteine synthesis.

Note: Reaction E.C. 1.8.99.4 was transferred to E.C 1.8.4.8 in 2000.

Enzyme Commission Summary:
Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species.

Citations: [Berendt95]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.8.4.8 , ENZYME:EC:1.8.4.8 , IUBMB-ExplorEnz:EC:1.8.4.8


References

Berendt95: Berendt U, Haverkamp T, Prior A, Schwenn JD (1995). "Reaction mechanism of thioredoxin: 3'-phospho-adenylylsulfate reductase investigated by site-directed mutagenesis." Eur J Biochem 1995;233(1);347-56. PMID: 7588765


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.