Escherichia coli K-12 substr. MG1655 RNA: RydC small regulatory RNA

Gene: rydC Accession Numbers: G0-10592 (EcoCyc), b4597, ECK4407

Superclasses: a regulatory RNA

Regulation Summary Diagram: ?

Regulation summary diagram for rydC

RydC is a small RNA regulator of the expression of yejABEF, which encodes a predicted ABC permease [Antal05], and of the transcriptional regulator CsgD [Bordeau14].

Hfq binds to RydC in vivo [Zhang03c] and in vitro and stabilizes it [Antal05]. RydC folds into a pseudoknot structure [Zhang03c]; Hfq facilitates unfolding of the pseudoknot and thereby enhances the interaction of RydC with its mRNA target [Bordeau14]. The yejABEF mRNA was found to bind the RydC-Hfq complex [Zhang03c].

A rydC deletion strain has no detectable growth defect, but overexpression of RydC leads to a temperature-sensitive growth defect on minimal medium with glycerol, maltose, or ribose as the carbon source and leads to degradation of yejABEF mRNA [Antal05].

RydC: "RNA of unknown function at X position (10 minute) in the genome"

Map Position: [1,489,467 <- 1,489,530] (32.1 centisomes, 116°)
Length: 64 bp

Unification Links: EcoGene:EG31168 , EcoliWiki:b4597 , PortEco:rydC , RegulonDB:G0-10592

GO Terms:

Biological Process: GO:0035194 - posttranscriptional gene silencing by RNA Inferred from experiment [Antal05]
Molecular Function: GO:0000499 - base pairing with mRNA Inferred from experiment [Bordeau14]
GO:0005515 - protein binding Inferred from experiment [Antal05]

MultiFun Terms: regulation type of regulation

Regulated Transcription Units (1 total): ?


Transcription-unit diagram

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram


Created 30-Apr-2007 by Keseler I , SRI International
Last-Curated ? 13-Feb-2014 by Keseler I , SRI International


Antal05: Antal M, Bordeau V, Douchin V, Felden B (2005). "A small bacterial RNA regulates a putative ABC transporter." J Biol Chem 280(9);7901-8. PMID: 15618228

Bordeau14: Bordeau V, Felden B (2014). "Curli synthesis and biofilm formation in enteric bacteria are controlled by a dynamic small RNA module made up of a pseudoknot assisted by an RNA chaperone." Nucleic Acids Res 42(7);4682-96. PMID: 24489123

Zhang03c: Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S (2003). "Global analysis of small RNA and mRNA targets of Hfq." Mol Microbiol 50(4);1111-24. PMID: 14622403

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, BIOCYC14A.