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Escherichia coli K-12 substr. MG1655 Polypeptide: predicted transcriptional regulator



Gene: ygeH Accession Numbers: G7472 (EcoCyc), b2852, ECK2850

Regulation Summary Diagram: ?

Summary:
ygeH is located within a remnant of an ETT2 (type III secretion system) pathogenicity island that is fully present in pathogenic strains such as E. coli O157:H7 and at least partially present in most sequenced E. coli and Shigella strains [Ren04b]. ETT2 has been shown to contribute to pathogenesis [Ideses05].

Locations: cytosol

Map Position: [2,990,116 -> 2,991,492] (64.45 centisomes)
Length: 1377 bp / 458 aa

Molecular Weight of Polypeptide: 52.753 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0009368 , EchoBASE:EB2853 , EcoGene:EG13038 , EcoliWiki:b2852 , ModBase:P76639 , OU-Microarray:b2852 , PortEco:ygeH , Pride:P76639 , Protein Model Portal:P76639 , RefSeq:NP_417329 , RegulonDB:G7472 , SMR:P76639 , String:511145.b2852 , UniProt:P76639

Relationship Links: InterPro:IN-FAMILY:IPR001867 , InterPro:IN-FAMILY:IPR011990 , InterPro:IN-FAMILY:IPR011991 , InterPro:IN-FAMILY:IPR013026 , InterPro:IN-FAMILY:IPR016032 , InterPro:IN-FAMILY:IPR019734 , Pfam:IN-FAMILY:PF00486 , Prosite:IN-FAMILY:PS50005 , Prosite:IN-FAMILY:PS50293 , Smart:IN-FAMILY:SM00862

GO Terms:

Biological Process: GO:0000160 - phosphorelay signal transduction system Inferred by computational analysis [GOA01]
GO:0006351 - transcription, DNA-templated Inferred by computational analysis [UniProtGOA11]
GO:0006355 - regulation of transcription, DNA-templated Inferred by computational analysis [UniProtGOA11, GOA01]
Molecular Function: GO:0003677 - DNA binding Inferred by computational analysis [UniProtGOA11, GOA01]
Cellular Component: GO:0005829 - cytosol Inferred from experiment Inferred by computational analysis [DiazMejia09, Watt07]

MultiFun Terms: regulation type of regulation transcriptional level

Essentiality data for ygeH knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB Lennox Yes 37 Aerobic 7   Yes [Baba06, Comment 1]
M9 medium with 1% glycerol Yes 37 Aerobic 7.2 0.35 Yes [Joyce06, Comment 2]
MOPS medium with 0.4% glucose Yes 37 Aerobic 7.2 0.22 Yes [Baba06, Comment 1]

Credits:
Last-Curated ? 22-Feb-2007 by Keseler I , SRI International


Sequence Features

Feature Class Location Citations Comment
Repeat 372 -> 405
[UniProt09]
UniProt: TPR;


Gene Local Context (not to scale): ?

Transcription Unit:

Notes:

History:
Markus Krummenacker on Tue Oct 14, 1997:
Gene object created from Blattner lab Genbank (v. M52) entry.


References

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

GOA01: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Ideses05: Ideses D, Gophna U, Paitan Y, Chaudhuri RR, Pallen MJ, Ron EZ (2005). "A degenerate type III secretion system from septicemic Escherichia coli contributes to pathogenesis." J Bacteriol 187(23);8164-71. PMID: 16291689

Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394

PerezRueda04: Perez-Rueda E, Collado-Vides J, Segovia L (2004). "Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea." Comput Biol Chem 28(5-6);341-50. PMID: 15556475

Ren04b: Ren CP, Chaudhuri RR, Fivian A, Bailey CM, Antonio M, Barnes WM, Pallen MJ (2004). "The ETT2 gene cluster, encoding a second type III secretion system from Escherichia coli, is present in the majority of strains but has undergone widespread mutational attrition." J Bacteriol 186(11);3547-60. PMID: 15150243

UniProt09: UniProt Consortium (2009). "UniProt version 15.8 released on 2009-10-01 00:00:00." Database.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

Watt07: Watt RM, Wang J, Leong M, Kung HF, Cheah KS, Liu D, Danchin A, Huang JD (2007). "Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes." Nucleic Acids Res 35(6);e37. PMID: 17272300


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc13.