|Gene:||ldrB||Accession Numbers: G0-9605 (EcoCyc), b4421, ECK1206|
ldrB is one of a set of four Long Direct Repeats (LDRs), one of which has been shown to code for the toxin portion of a toxin-antitoxin pair.
ldrA, ldrB and ldrC are clustered together as tandem repeats, with ldrD elsewhere on the genome. LdrD is toxic when overexpressed and appears to be the toxin member of a toxin-antitoxin pair [Kawano02]. Deletions of ldrABC, ldrD and ldrABCD have no effect under laboratory conditions [Kawano02].
Four LDR-like regions, three near ldrD, one near ldrABC, may represent recombination spots for LDRs [Kawano02a].
|Map Position: [1,268,926 <- 1,269,033] (27.35 centisomes, 98°)||Length: 108 bp / 35 aa|
Molecular Weight of Polypeptide: 3.972 kD (from nucleotide sequence)
Unification Links: ASAP:ABE-0047281 , EchoBASE:EB4336 , EcoGene:EG14404 , EcoliWiki:b4421 , PortEco:ldrB , PR:PRO_000023076 , Protein Model Portal:Q6BF87 , RefSeq:YP_025298 , RegulonDB:G0-9605 , String:511145.b4421 , UniProt:Q6BF87
|Biological Process:||GO:0012501 - programmed cell death [Kawano02]|
|MultiFun Terms:||cell processes → protection → cell killing|
Kawano02: Kawano M, Oshima T, Kasai H, Mori H (2002). "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli." Mol Microbiol 45(2);333-49. PMID: 12123448
Kawano02a: Kawano M, Kanaya S, Oshima T, Masuda Y, Ara T, Mori H (2002). "Distribution of repetitive sequences on the leading and lagging strands of the Escherichia coli genome: comparative study of Long Direct Repeat (LDR) sequences." DNA Res 9(1);1-10. PMID: 11939563
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