Escherichia coli K-12 substr. MG1655 Polypeptide: toxic peptide IbsC

Gene: ibsC Accession Numbers: G0-10631 (EcoCyc), b4665, ECK4480

Regulation Summary Diagram: ?

Regulation summary diagram for ibsC

The small open reading frame IbsC was detected by similarity to the open reading frames encoded on the opposite strand of the sib small RNAs [Fozo08]. It was later found that overexpression of a SibC antisense RNA suppresses cell growth, which can be attributed to the production of the toxic peptide IbsC [Mok09].

Overexpression of IbsC is toxic to the cell by disrupting membrane integrity. Whole-genome gene expression analysis after induction of IsbC expression shows changes in expression of many stress response and membrane proteins [Fozo08].

IbsC: "induction brings stasis" [Fozo08]

Map Position: [3,054,912 <- 3,054,971] (65.84 centisomes, 237°)
Length: 60 bp / 19 aa

Molecular Weight of Polypeptide: 2.209 kD (from nucleotide sequence)

Unification Links: EcoGene:EG14470 , PortEco:ibsC , PR:PRO_000022985 , RegulonDB:G0-10631 , UniProt:C1P615

Relationship Links: InterPro:IN-FAMILY:IPR025881 , Pfam:IN-FAMILY:PF13956

GO Terms:

Biological Process: GO:0012501 - programmed cell death Inferred from experiment [Fozo08]

MultiFun Terms: cell processes

Created 27-Aug-2008 by Keseler I , SRI International
Last-Curated ? 13-Mar-2009 by Keseler I , SRI International

Gene Local Context (not to scale): ?

Gene local context diagram

The database does not contain any information about transcription units for this gene.


Fozo08: Fozo EM, Kawano M, Fontaine F, Kaya Y, Mendieta KS, Jones KL, Ocampo A, Rudd KE, Storz G (2008). "Repression of small toxic protein synthesis by the Sib and OhsC small RNAs." Mol Microbiol 70(5):1076-93. PMID: 18710431

Mok09: Mok WW, Navani NK, Barker C, Sawchyn BL, Gu J, Pathania R, Zhu RD, Brown ED, Li Y (2009). "Identification of a toxic peptide through bidirectional expression of small RNAs." Chembiochem 10(2);238-41. PMID: 19090519

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc13.