Escherichia coli K-12 substr. MG1655 RNA: Qin prophage; DicF antisense RNA

Gene: dicF Accession Numbers: EG31115 (EcoCyc), b1574, ECK1568

Superclasses: a regulatory RNA

Regulation Summary Diagram: ?

Regulation summary diagram for dicF

The DicF RNA acts to inhibit cell division [Bouche89]. DicF causes inhibition of the formation of the constriction and the separation of the replicated chromosomes into the daughter nucleoids [Tetart92]. DicF RNA interferes with FtsZ mRNA translation [Tetart92a]; DicF may bind to and occlude the ribosome binding site on the FtsZ mRNA [Tetart92a].

The DicF-mediated delay in nucleoid segregation is suppressed by FtsZ overproduction [Tetart92]. The DicF-mediated decrease in FtsZ abundance and activity is suppressed by an rpoB mutation, and this effect is partially counteracted by an rpoS mutation [Cam95].

The DicF RNA is subject to processing by RNase III and RNase E [Faubladier90].

The DicF gene has similarity to multiple prophage sequences [Faubladier94].

Regulation has been described [Faubladier90].

Reviews: [Delihas95, Wassarman99].

Map Position: [1,647,406 -> 1,647,458] (35.51 centisomes, 128°)
Length: 53 bp

Unification Links: ASAP:ABE-0005257 , CGSC:32240 , EchoBASE:EB4278 , EcoGene:EG31115 , EcoliWiki:b1574 , OU-Microarray:b1574 , PortEco:dicF , RegulonDB:EG31115

GO Terms:

Biological Process: GO:0007049 - cell cycle

MultiFun Terms: cell processes cell cycle physiology
cell processes cell division
extrachromosomal prophage genes and phage related functions
information transfer RNA related antisense RNA
regulation type of regulation posttranscriptional antisense RNA

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram


10/20/97 Gene b1574 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG31115.


Bouche89: Bouche F, Bouche JP (1989). "Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA." Mol Microbiol 3(7);991-4. PMID: 2477663

Cam95: Cam K, Cuzange A, Bouche JP (1995). "Sigma S-dependent overexpression of ftsZ in an Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA." Mol Gen Genet 248(2);190-4. PMID: 7651342

Delihas95: Delihas N (1995). "Regulation of gene expression by trans-encoded antisense RNAs." Mol Microbiol 15(3);411-4. PMID: 7540245

Faubladier90: Faubladier M, Cam K, Bouche JP (1990). "Escherichia coli cell division inhibitor DicF-RNA of the dicB operon. Evidence for its generation in vivo by transcription termination and by RNase III and RNase E-dependent processing." J Mol Biol 212(3);461-71. PMID: 1691299

Faubladier94: Faubladier M, Bouche JP (1994). "Division inhibition gene dicF of Escherichia coli reveals a widespread group of prophage sequences in bacterial genomes." J Bacteriol 176(4);1150-6. PMID: 7508908

Tetart92: Tetart F, Albigot R, Conter A, Mulder E, Bouche JP (1992). "Involvement of FtsZ in coupling of nucleoid separation with septation." Mol Microbiol 6(5);621-7. PMID: 1552861

Tetart92a: Tetart F, Bouche JP (1992). "Regulation of the expression of the cell-cycle gene ftsZ by DicF antisense RNA. Division does not require a fixed number of FtsZ molecules." Mol Microbiol 6(5);615-20. PMID: 1372677

Wassarman99: Wassarman KM, Zhang A, Storz G (1999). "Small RNAs in Escherichia coli." Trends Microbiol 7(1);37-45. PMID: 10068996

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.