|Gene:||dicF||Accession Numbers: EG31115 (EcoCyc), b1574, ECK1568|
Superclasses: a regulatory RNA
The DicF RNA acts to inhibit cell division [Bouche89]. DicF causes inhibition of the formation of the constriction and the separation of the replicated chromosomes into the daughter nucleoids [Tetart92]. DicF RNA interferes with FtsZ mRNA translation [Tetart92a]; DicF may bind to and occlude the ribosome binding site on the FtsZ mRNA [Tetart92a].
The DicF-mediated delay in nucleoid segregation is suppressed by FtsZ overproduction [Tetart92]. The DicF-mediated decrease in FtsZ abundance and activity is suppressed by an rpoB mutation, and this effect is partially counteracted by an rpoS mutation [Cam95].
The DicF RNA is subject to processing by RNase III and RNase E [Faubladier90].
The DicF gene has similarity to multiple prophage sequences [Faubladier94].
Regulation has been described [Faubladier90].
|Map Position: [1,647,406 -> 1,647,458] (35.51 centisomes, 128°)||Length: 53 bp|
|Biological Process:||GO:0007049 - cell cycle|
|MultiFun Terms:||cell processes → cell cycle physiology|
|cell processes → cell division|
|extrachromosomal → prophage genes and phage related functions|
|information transfer → RNA related → antisense RNA|
|regulation → type of regulation → posttranscriptional → antisense RNA|
10/20/97 Gene b1574 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG31115.
Cam95: Cam K, Cuzange A, Bouche JP (1995). "Sigma S-dependent overexpression of ftsZ in an Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA." Mol Gen Genet 248(2);190-4. PMID: 7651342
Faubladier90: Faubladier M, Cam K, Bouche JP (1990). "Escherichia coli cell division inhibitor DicF-RNA of the dicB operon. Evidence for its generation in vivo by transcription termination and by RNase III and RNase E-dependent processing." J Mol Biol 212(3);461-71. PMID: 1691299
Faubladier94: Faubladier M, Bouche JP (1994). "Division inhibition gene dicF of Escherichia coli reveals a widespread group of prophage sequences in bacterial genomes." J Bacteriol 176(4);1150-6. PMID: 7508908
Tetart92a: Tetart F, Bouche JP (1992). "Regulation of the expression of the cell-cycle gene ftsZ by DicF antisense RNA. Division does not require a fixed number of FtsZ molecules." Mol Microbiol 6(5);615-20. PMID: 1372677
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