Escherichia coli K-12 substr. MG1655 Polypeptide: predicted dehydrogenase, NAD-dependent

Gene: yeiP Accession Numbers: EG12035 (EcoCyc), b2171, ECK2165

Regulation Summary Diagram: ?

Regulation summary diagram for yeiP

YeiP is a hypothetical protein. Sequence similarity suggests that it may contain β-barrel structure(s) [Zhai02]

Locations: cytosol

Map Position: [2,263,472 -> 2,264,044] (48.79 centisomes, 176°)
Length: 573 bp / 190 aa

Molecular Weight of Polypeptide: 21.533 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0007187 , EchoBASE:EB1970 , EcoGene:EG12035 , EcoliWiki:b2171 , Mint:MINT-1302160 , ModBase:P0A6N8 , OU-Microarray:b2171 , PortEco:yeiP , Pride:P0A6N8 , Protein Model Portal:P0A6N8 , RefSeq:NP_416676 , RegulonDB:EG12035 , SMR:P0A6N8 , String:511145.b2171 , UniProt:P0A6N8

Relationship Links: InterPro:IN-FAMILY:IPR001059 , InterPro:IN-FAMILY:IPR008991 , InterPro:IN-FAMILY:IPR011897 , InterPro:IN-FAMILY:IPR012340 , InterPro:IN-FAMILY:IPR013185 , InterPro:IN-FAMILY:IPR013852 , InterPro:IN-FAMILY:IPR014722 , InterPro:IN-FAMILY:IPR015365 , InterPro:IN-FAMILY:IPR020599 , Pfam:IN-FAMILY:PF01132 , Pfam:IN-FAMILY:PF08207 , Pfam:IN-FAMILY:PF09285 , Prosite:IN-FAMILY:PS01275 , Smart:IN-FAMILY:SM00841

In Paralogous Gene Group: 386 (2 members)

Genetic Regulation Schematic: ?

Genetic regulation schematic for yeiP

GO Terms:

Biological Process: GO:0006414 - translational elongation Inferred by computational analysis [GOA06, GOA01]
GO:0043043 - peptide biosynthetic process Inferred by computational analysis [GOA01]
Molecular Function: GO:0003746 - translation elongation factor activity Inferred by computational analysis [GOA06, GOA01]
Cellular Component: GO:0005829 - cytosol Inferred from experiment Inferred by computational analysis [DiazMejia09, LopezCampistrou05]
GO:0005737 - cytoplasm Inferred by computational analysis [GOA01]

Gene Class: ORFs

Essentiality data for yeiP knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB enriched Yes 37 Aerobic 6.95   Yes [Gerdes03, Comment 1]
LB Lennox Yes 37 Aerobic 7   Yes [Baba06, Comment 2]
M9 medium with 1% glycerol Yes 37 Aerobic 7.2 0.35 Yes [Joyce06, Comment 3]
MOPS medium with 0.4% glucose Yes 37 Aerobic 7.2 0.22 Yes [Baba06, Comment 2]

Last-Curated ? 10-Jul-2006 by Keseler I , SRI International

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Units:

Transcription-unit diagram

Transcription-unit diagram


Peter D. Karp on Wed Jan 18, 2006:
Gene left-end position adjusted based on analysis performed in the 2005 E. coli annotation update [Riley06 ].
10/20/97 Gene b2171 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG12035; confirmed by SwissProt match.


Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Gerdes03: Gerdes SY, Scholle MD, Campbell JW, Balazsi G, Ravasz E, Daugherty MD, Somera AL, Kyrpides NC, Anderson I, Gelfand MS, Bhattacharya A, Kapatral V, D'Souza M, Baev MV, Grechkin Y, Mseeh F, Fonstein MY, Overbeek R, Barabasi AL, Oltvai ZN, Osterman AL (2003). "Experimental determination and system level analysis of essential genes in Escherichia coli MG1655." J Bacteriol 185(19);5673-84. PMID: 13129938

GOA01: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."

Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394

LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532

Riley06: Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR, Chaudhuri RR, Glasner JD, Horiuchi T, Keseler IM, Kosuge T, Mori H, Perna NT, Plunkett G, Rudd KE, Serres MH, Thomas GH, Thomson NR, Wishart D, Wanner BL (2006). "Escherichia coli K-12: a cooperatively developed annotation snapshot--2005." Nucleic Acids Res 34(1);1-9. PMID: 16397293

Zhai02: Zhai Y, Saier MH (2002). "The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes." Protein Sci 11(9);2196-207. PMID: 12192075

Other References Related to Gene Regulation

Raghavan11: Raghavan R, Sage A, Ochman H (2011). "Genome-wide identification of transcription start sites yields a novel thermosensing RNA and new cyclic AMP receptor protein-regulated genes in Escherichia coli." J Bacteriol 193(11);2871-4. PMID: 21460078

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc13.