Escherichia coli K-12 substr. MG1655 Compound: Zn2+

Synonyms: Zn, Zinc, Zn+2, Zn++, zinc ion, Zn(II)

Superclasses: an iona cationan inorganic cationa divalent inorganic cation
an ionan inorganic ionan inorganic cationa divalent inorganic cation

Component of:
zinc hydrogenphosphate
zinc sulfate heptahydrate
zinc sulfate
NrdR-Zn2+ DNA-binding transcriptional repressor
Zur-Zn2+ DNA-binding transcriptional repressor (extended summary available)
ZntR-Zn2+ transcriptional activator

Chemical Formula: Zn

Molecular Weight: 65.38 Daltons

Monoisotopic Molecular Weight: 63.9291466 Daltons

SMILES: [Zn++]

InChI: InChI=1S/Zn/q+2


Unification Links: CAS:7440-66-6, ChEBI:29105, ChemSpider:29723, HMDB:HMDB01303, IAF1260:33614, KEGG:C00038, MetaboLights:MTBLC29105, PubChem:32051

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): 0.0

In Reactions of unknown directionality:

Not in pathways:
NrdR + Zn2+ = NrdR-Zn2+ DNA-binding transcriptional repressor
Zur + Zn2+ = Zur transcriptional repressor
ZntR + Zn2+ = ZntR transcriptional activator

In Transport reactions:
Zn2+[periplasm] + ATP + H2O → Zn2+[cytosol] + ADP + phosphate + H+,
Zn2+[cytosol] + H+[periplasm]Zn2+[periplasm] + H+[cytosol],
Zn2+[cytosol] + ATP + H2O → Zn2+[periplasm] + ADP + phosphate + H+,
an ion[periplasm]an ion[extracellular space]

Enzymes activated by Zn2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: dipeptidyl carboxypeptidase [Chen09], GTPase [BlabyHaas12], D-mannonate oxidoreductase [Portalier72], nonspecific dipeptidase [Schroeder94], Ap4A synthetase [Plateau82, Charlier87], Ap3A synthetase [Plateau82]

Enzymes inhibited by Zn2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: cytosine deaminase [Porter93, Comment 1], ornithine carbamoyltransferase [Comment 2], ornithine carbamoyltransferase [Comment 3] Inhibitor (Allosteric) of: diguanylate cyclase [Zahringer13] Inhibitor (Mechanism unknown) of: tail-specific protease [Park88], lipopolysaccharide glucosyltransferase [Qian14], non-heme bacterial ferritin [Treffry98], pyridine nucleotide transhydrogenase [Cao11], GTPase [Sydor13], fumarase A [Xu12], malate dehydrogenase [Wang11], glyoxalase [Subedi11], adenosylmethionine decarboxylase [Lu07], guanosine kinase [Mori95], inosine kinase [Mori95], L-serine deaminase [Newman80], 7-α-hydroxysteroid dehydrogenase [Yoshimoto91], S-formylglutathione hydrolase [Gonzalez06], S-formylglutathione hydrolase [Gonzalez06], glycolate oxidase [Lord72], imidazoleglycerol-phosphate dehydratase [Brady73], betaine aldehyde dehydrogenase [Falkenberg90], methylmalonyl-CoA mutase [Bobik03], glycolaldehyde dehydrogenase [Baldoma87], L-1,2-propanediol oxidoreductase [Obradors98, Montella05], glycolaldehyde reductase [Obradors98], deoxyribose 1,5-phosphomutase [HammerJespersen70], 3'-nucleotidase [Anraku64], glutamate decarboxylase B [Helmward89], 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80], ubiquinol oxidase (H+-transporting) [Helmward89, Kita86, Kita84], glycogen phosphorylase [Chen68, Chen68a], fructoselysine 3-epimerase [Wiame04], N-acetylglutamylphosphate reductase [Vogel74], adenylosuccinate synthetase [Kang95], methylglyoxal reductase (NADPH-dependent) [Saikusa87], acetylornithine deacetylase [Vogel74a, JavidMajd00], D-glucuronate isomerase [Ashwell60], D-galacturonate isomerase [Ashwell60], argininosuccinate lyase [Vogel74], lysyl-tRNA synthetase [Plateau82, Charlier87], UDP-3-O-acyl-N-acetylglucosamine deacetylase [Jackman99], phenylalanyl-tRNA synthetase [Mayaux81], dipeptidyl carboxypeptidase [Henrich93], tetrahydrodipicolinate succinylase [Simms84], amylomaltase [Wiesmeyer60], polyphosphate kinase [Haeusler92], adenine phosphoribosyltransferase [Hochstadt78], glutamate decarboxylase A [Helmward89], hypoxanthine phosphoribosyltransferase [Hochstadt78a], N-acetylglutamate synthase [Marvil77], selenide, water dikinase [Veres94, Kim93, Kim94], fructoselysine 6-phosphate deglycase [Wiame02], taurine dioxygenase [Eichhorn97], 2',3'-cyclic nucleotide 2'-phosphodiesterase [Anraku64], D-aminopropanol dehydrogenase [Kelley84, Campbell78], α-galactosidase [Burstein71], D-arabinose 5-phosphate isomerase [Meredith05] Inhibitor (Other types) of: D-arabinose 5-phosphate isomerase [Lim66, Meredith03, Airoldi10]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: dipeptidyl carboxypeptidase, methionine synthase, L-galactitol-1-phosphate 5-dehydrogenase, glyoxalase II, methionyl-tRNA synthetase, fructose bisphosphate aldolase, L-galactonate oxidoreductase, 3-dehydroquinate synthase, alkaline phosphatase, mannose-6-phosphate isomerase, ribonucleoside-triphosphate reductase, UDP-sugar hydrolase, threonine dehydrogenase, rhamnulose-1-phosphate aldolase, carbonic anhydrase, alkaline phosphatase, 5'-ribonucleotidase, tRNA-guanine transglycosylase, UDP-glucose:α-D-galactose-1-phosphate uridylyltransferase, metallopeptidase, diacylglycerol kinase, allantoinase, aldehyde reductase, D-glucuronate isomerase, L-ribulose 5-phosphate 4-epimerase, anhydro-N-acetylmuramoyl-L-alanine amidase, D-ribulose-phosphate aldolase, L-fuculose-phosphate aldolase, N-acetylglucosamine-6-phosphate deacetylase, tRNA adenosine deaminase, carbonic anhydrase, glyoxalase II, isopentenyl diphosphate isomerase, dihydroorotase, threonyl-tRNA synthetase, cysteinyl-tRNA synthetase, alanyl-tRNA synthetase, aminopeptidase, GTP cyclohydrolase, guanine deaminase, 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent, ATP-dependent zinc metalloendoprotease, isoleucyl-tRNA synthetase, porphobilinogen synthase, acetylornithine deacetylase, methionyl-tRNA synthetase, glutamyl-tRNA synthetase, cobalamin-independent homocysteine transmethylase, deoxyuridine triphosphatase, acyl carrier protein phosphodiesterase, isoaspartyl dipeptidase, 3-demethylubiquinone-8 3-O-methyltransferase, N-succinyl-L-diaminopimelate desuccinylase, formaldehyde dehydrogenase, 23S rRNA m1G745 methyltransferase, cytidine deaminase, deoxycytidine deaminase

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: methionine adenosyltransferase, cytosine deaminase, NMN adenylyltransferase, carbamoyl phosphate synthetase

Activates: ZraS + ATP → ZraS-Phis254 + ADP

In Growth Media: MOPS medium with 2% glycerol, MOPS medium with 2% glucose, MOPS medium with 0.4% glucose, MOPS medium base, Neidhardt EZ rich defined medium, trace metal solution, LB enriched, M56 medium

Transcription Units regulated by related protein NrdR-Zn2+ DNA-binding transcriptional repressor (3 total):

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Transcription Units regulated by related protein Zur-Zn2+ DNA-binding transcriptional repressor (5 total):

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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