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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Compound: Ni2+

Synonyms: nickel, Ni++, Ni+2

Superclasses: an ion a cation

Component of:
nickel sulphate
YqjI-nickel
RcnR-nickel
NikR-Ni transcriptional repressor

Chemical Formula: Ni

Molecular Weight: 58.7 Daltons

Monoisotopic Molecular Weight: 59.9509979642 Daltons

SMILES: [Ni++]

InChI: InChI=1S/Ni/q+2

InChIKey: InChIKey=VEQPNABPJHWNSG-UHFFFAOYSA-N

Unification Links: ChEBI:49786 , ChemSpider:909 , HMDB:HMDB02457 , IAF1260:34516 , KEGG:C19609 , PubChem:934

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

In Reactions of unknown directionality:

Not in pathways:
YqjI + Ni2+ = YqjI-nickel
RcnR + Ni2+ = RcnR-nickel
NikR + Ni2+ = NikR-Ni transcriptional repressor

In Transport reactions:
Ni2+[periplasmic space]Ni2+[cytosol] ,
Ni2+[periplasmic space] + ATP + H2O → Ni2+[cytosol] + ADP + phosphate + H+ ,
Ni2+[cytosol]Ni2+[periplasmic space]

Enzymes activated by Ni2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: cysteinylglycine dipeptidase [Suzuki01b] , fructoselysine 3-epimerase [Wiame04] , argininosuccinate lyase [Vogel74]

Enzymes inhibited by Ni2+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: GTPase [Sydor13] , glutamate-5-semialdehyde dehydrogenase [Hayzer82] , N-acetylglutamylphosphate reductase [Vogel74] , methylglyoxal reductase (NADPH-dependent) [Saikusa87] , acetylornithine deacetylase [Vogel74b] , dipeptidyl carboxypeptidase [Henrich93] , threonine dehydrogenase [Boylan81, Craig86] , amylomaltase [Wiesmeyer60] , D-aminopropanol dehydrogenase [Kelley84, Campbell78] , α-galactosidase [Burstein71]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: ureidoglycolate lyase , 5'-nucleotidase , 3'-nucleotidase , hydrogenase , hydrogenase , aminopeptidase , examinopeptidase , glyoxalase I


References

Boylan81: Boylan SA, Dekker EE (1981). "L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12." J Biol Chem 1981;256(4);1809-15. PMID: 6780553

Burstein71: Burstein C, Kepes A (1971). "The alpha-galactosidase from Escherichia coli K12." Biochim Biophys Acta 1971;230(1);52-63. PMID: 5543331

Campbell78: Campbell RL, Swain RR, Dekker EE (1978). "Purification, separation, and characterization of two molecular forms of D-1-amino-2-propanol:NAD+ oxidoreductase activity from extracts of Escherichia coli K-12." J Biol Chem 253(20);7282-8. PMID: 359547

Craig86: Craig PA, Dekker EE (1986). "L-threonine dehydrogenase from Escherichia coli K-12: thiol-dependent activation by Mn2+." Biochemistry 1986;25(8);1870-6. PMID: 3518793

Hayzer82: Hayzer DJ, Leisinger T (1982). "Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase." Eur J Biochem 1982;121(3);561-5. PMID: 7035170

Henrich93: Henrich B, Becker S, Schroeder U, Plapp R (1993). "dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product." J Bacteriol 175(22);7290-300. PMID: 8226676

Kelley84: Kelley JJ, Dekker EE (1984). "D-1-amino-2-propanol:NAD+ oxidoreductase. Purification and general properties of the large molecular form of the enzyme from Escherichia coli K12." J Biol Chem 1984;259(4);2124-9. PMID: 6365902

Saikusa87: Saikusa T, Rhee H, Watanabe K, Murata K, Kimura A (1987). "Metabolism of 2-oxoaldehydes in bacteria: purification and characterization of methylglyoxal reductase from E. coli." Agricultural and Biological Chemistry 51(7): 1893-1899.

Suzuki01b: Suzuki H, Kamatani S, Kumagai H (2001). "Purification and characterization of aminopeptidase B from Escherichia coli K-12." Biosci Biotechnol Biochem 65(7);1549-58. PMID: 11515538

Sydor13: Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB (2013). "Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases." Biochemistry 52(10);1788-1801. PMID: 24449932

Vogel74: Vogel HJ, Vogel RH (1974). "Enzymes of arginine biosynthesis and their repressive control." Adv Enzymol Relat Areas Mol Biol 1974;40(0);65-90. PMID: 4365537

Vogel74b: Vogel, HJ, Vogel, RH "Enzymes of Arginine Biosynthesis." Advances in Enzymology 40:71-72 (1974).

Wiame04: Wiame E, Van Schaftingen E (2004). "Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli." Biochem J 378(Pt 3);1047-52. PMID: 14641112

Wiesmeyer60: Wiesmeyer H, Cohn M (1960). "The characterization of the pathway of maltose utilization by Escherichia coli: II. General properties and mechanism of action of amylomaltase." Biochim Biophys Acta 39:427-439. PMID: 13844669


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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