Escherichia coli K-12 substr. MG1655 Compound: histidinol

Synonyms: histidol, L-histidinol

Chemical Formula: C6H12N3O

Molecular Weight: 142.18 Daltons

Monoisotopic Molecular Weight: 142.0980370229 Daltons

histidinol compound structure


InChI: InChI=1S/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/p+1/t5-/m0/s1


Unification Links: CAS:501-28-0, ChEBI:57699, HMDB:HMDB03431, IAF1260:36226, KEGG:C00860, KNApSAcK:C00007479, PubChem:6950298

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): -14.22

Reactions known to consume the compound:

L-histidine biosynthesis :
histidinol + NAD+ → histidinal + NADH + H+

Reactions known to produce the compound:

L-histidine biosynthesis :
L-histidinol-phosphate + H2O → histidinol + phosphate

In Reactions of unknown directionality:

Not in pathways:
histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+

Enzymes inhibited by histidinol, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: histidyl-tRNA synthetase [Kalousek74], histidinol-phosphatase [Brady73]


Brady73: Brady DR, Houston LL (1973). "Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium." J Biol Chem 1973;248(7);2588-92. PMID: 4349042

Kalousek74: Kalousek F, Konigsberg WH (1974). "Purification and characterization of histidyl transfer ribonucleic acid synthetase of Escherichia coli." Biochemistry 13(5);999-1006. PMID: 4591623

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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