Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Compound: glycerol

Synonyms: 1,2,3-trihydroxypropane, glycerin, 1,2,3-trihydroxypropanol

Superclasses: all carbohydrates a carbohydrate a glycan a sugar a sugar alcohol
an alcohol a sugar alcohol

Component of: GlpR-glycerol

Chemical Formula: C3H8O3

Molecular Weight: 92.094 Daltons

Monoisotopic Molecular Weight: 92.0473441231 Daltons

SMILES: C(C(O)CO)O

InChI: InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChIKey: InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N

Unification Links: CAS:56-81-5 , ChEBI:17754 , ChemSpider:733 , DrugBank:DB04077 , HMDB:HMDB00131 , IAF1260:33915 , KEGG:C00116 , MetaboLights:MTBLC17754 , PubChem:753

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -118.9

Reactions known to consume the compound:

glycerol degradation I :
glycerol + ATP → sn-glycerol 3-phosphate + ADP + H+

Reactions known to produce the compound:

cardiolipin biosynthesis I :
2 an L-1-phosphatidyl-glycerol → a cardiolipin + glycerol

Not in pathways:
glycerol 2-phosphate + H2O → glycerol + phosphate
glycerol 1-phosphate + H2O → glycerol + phosphate
glycerophosphoglycerol + H2O → glycerol + sn-glycerol 3-phosphate + H+


a sugar phosphate + H2O → a sugar + phosphate

β-D-glucuronide and D-glucuronate degradation :
a β-D-glucuronoside + H2O → D-glucopyranuronate + an alcohol

glycerophosphodiester degradation :
a glycerophosphodiester + H2O → an alcohol + sn-glycerol 3-phosphate + H+


an alcohol + NAD+ + H2O ← an organic hydroperoxide + NADH + H+
an N-acetyl-β-D-hexosaminide + H2O → an N-acetyl-β-D-hexosamine + an alcohol
a carboxylic ester + H2O → an alcohol + a carboxylate + H+
an acetic ester + H2O → an alcohol + acetate + H+
an organic hydroperoxide + a reduced thioredoxin → an alcohol + an oxidized thioredoxin + H2O
a phosphate monoester[periplasmic space] + H2O[periplasmic space]an alcohol[periplasmic space] + phosphate[periplasmic space]
a phosphate monoester[periplasmic space] + H2O[periplasmic space]an alcohol[periplasmic space] + phosphate[periplasmic space]

Reactions known to both consume and produce the compound:

glycerol degradation V :
glycerol + NAD+ ↔ dihydroxyacetone + NADH + H+

In Reactions of unknown directionality:

Not in pathways:
GlpR + glycerol = GlpR-glycerol


an alcohol + NADP+ = an aldehyde + NADPH + H+

In Transport reactions:
glycerol[periplasmic space]glycerol[cytosol] ,
a [PTS enzyme I]-Nπ-phospho-L-histidine + a sugar[periplasmic space] → a [PTS enzyme I]-L-histidine + a sugar phosphate[cytosol]

Enzymes inhibited by glycerol, sorted by the type of inhibition, are:

Inhibitor (Uncompetitive) of: fructose 6-phosphate aldolase [Schurmann01]

Inhibitor (Mechanism unknown) of: glycerol kinase [Pettigrew90, Comment 1]

In Growth Media: MOPS medium with 2% glycerol , M63 medium with 2% glycerol , M9 medium with 2% glycerol , M9 medium with 1% glycerol , ATCC medium 57 , PMA carbon source test + glycerol


References

Pettigrew90: Pettigrew DW, Yu GJ, Liu Y (1990). "Nucleotide regulation of Escherichia coli glycerol kinase: initial-velocity and substrate binding studies." Biochemistry 1990;29(37);8620-7. PMID: 2148683

Schurmann01: Schurmann M, Sprenger GA (2001). "Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases." J Biol Chem 2001;276(14);11055-61. PMID: 11120740


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 21, 2014, BIOCYC14A.