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Escherichia coli K-12 substr. MG1655 Compound: fluoride

Synonyms: fluoride ion, F-, F

Superclasses: an ionan anionan inorganic aniona halide anion
an ionan inorganic ionan inorganic aniona halide anion

Component of: NaF

Molecular Weight: 18.998 Daltons

Monoisotopic Molecular Weight: 20.0062282321 Daltons


InChI: InChI=1S/FH/h1H/p-1


Unification Links: ChEBI:17051, ChemSpider:26214, HMDB:HMDB00662, KEGG:C00742, PubChem:28179

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): 0.0

In Transport reactions:
an ion[periplasm]an ion[extracellular space]

Enzymes activated by fluoride, sorted by the type of activation, are:

Activator (Mechanism unknown) of: glycogen phosphorylase [Chen68, Chen68a]

Enzymes inhibited by fluoride, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: inorganic pyrophosphatase [Josse66a, Baykov00], phosphoenolpyruvate synthetase [Cooper65, McCormick15], α-dehydro-β-deoxy-D-glucarate aldolase [Fish66], enolase [Spring71], phosphoserine phosphatase [Pizer63], guanylate cyclase [Comment 1]


Baykov00: Baykov AA, Fabrichniy IP, Pohjanjoki P, Zyryanov AB, Lahti R (2000). "Fluoride effects along the reaction pathway of pyrophosphatase: evidence for a second enzyme.pyrophosphate intermediate." Biochemistry 39(39);11939-47. PMID: 11009607

Chen68: Chen GS, Segel IH (1968). "Purification and properties of glycogen phosphorylase from Escherichia coli." Arch Biochem Biophys 1968;127(1);175-86. PMID: 4878695

Chen68a: Chen GS, Segel IH (1968). "Escherichia coli polyglucose phosphorylases." Arch Biochem Biophys 1968;127(1);164-74. PMID: 4878694

Cooper65: Cooper RA, Kornberg HL (1965). "Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli." Biochim Biophys Acta 104(2);618-20. PMID: 5322808

Fish66: Fish D, Blumenthal H "2-keto-3-deoxy-D-glucarate aldolase." Meth Enz 1966;9:529-534.

Josse66a: Josse J (1966). "Constitutive inorganic pyrophosphatase of Escherichia coli. 1. Purification and catalytic properties." J Biol Chem 1966;241(9);1938-47. PMID: 5329747

Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852

McCormick15: McCormick NE, Jakeman DL (2015). "On the mechanism of phosphoenolpyruvate synthetase (PEPs) and its inhibition by sodium fluoride: potential magnesium and aluminum fluoride complexes of phosphoryl transfer." Biochem Cell Biol 93(3);236-40. PMID: 25707819

Pizer63: Pizer LI (1963). "The pathway and control of serine biosynthesis in Escherichia coli." J Biol Chem 1963;238:3934-3944. PMID: 14086727

Spring71: Spring TG, Wold F (1971). "The purification and characterization of Escherichia coli enolase." J Biol Chem 1971;246(22);6797-802. PMID: 4942326

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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