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Escherichia coli K-12 substr. MG1655 Compound: fumagillin

Chemical Formula: C26H33O7

Molecular Weight: 457.54 Daltons

Monoisotopic Molecular Weight: 458.2304534461 Daltons

SMILES: CC(C)=CCC1(C(C)(O1)C3(C2(OC2)CCC(OC(=O)C=CC=CC=CC=CC([O-])=O)C(OC)3))

InChI: InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/p-1/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1

InChIKey: InChIKey=NGGMYCMLYOUNGM-CSDLUJIJSA-M

Unification Links: ChEBI:48635 , KEGG:C09668 , LIPID MAPS:LMPR0103060003 , MetaboLights:MTBLC48635 , PubChem:40473208

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -93.46

Enzymes inhibited by fumagillin, sorted by the type of inhibition, are:

Inhibitor (Irreversible) of: methionine aminopeptidase [Lowther98]


References

Lowther98: Lowther WT, McMillen DA, Orville AM, Matthews BW (1998). "The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase." Proc Natl Acad Sci U S A 95(21);12153-7. PMID: 9770455


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14A.