Escherichia coli K-12 substr. MG1655 Compound: phenyl-thiazolylurea-sulfonamides

Superclasses: an organosulfur compound

Chemical Formula: C10H9N4O3S2

Molecular Weight: 297.33 Daltons

Monoisotopic Molecular Weight: 298.01943158809996 Daltons

phenyl-thiazolylurea-sulfonamides compound structure

SMILES: C1(=CN=C(S1)N(S(=O)(=O)[N-]C(=O)N)C2(=CC=CC=C2))

InChI: InChI=1S/C10H10N4O3S2/c11-9(15)13-19(16,17)14(10-12-6-7-18-10)8-4-2-1-3-5-8/h1-7H,(H3,11,13,15)/p-1


Unification Links: PubChem:25244894

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -69.21

In Transport reactions:
an organosulfur compound[periplasm]an organosulfur compound[extracellular space]

Enzymes inhibited by phenyl-thiazolylurea-sulfonamides, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: phenylalanyl-tRNA synthetase [Beyer04]


Beyer04: Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, Bauser M, Pohlmann J, Brands M, Ziegelbauer K, Haebich D, Eymann C, Brotz-Oesterhelt H (2004). "New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity." Antimicrob Agents Chemother 48(2);525-32. PMID: 14742205

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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