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Escherichia coli K-12 substr. MG1655 Compound: azaguanine

Synonyms: 8-azaguanine

Chemical Formula: C4H4N6O

Monoisotopic Molecular Weight: 152.0446587817 Daltons

SMILES: C2(=O)(C1(N=NNC=1NC(=N)N2))

InChI: InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)

InChIKey: InChIKey=LPXQRXLUHJKZIE-UHFFFAOYSA-N

Unification Links: ChEBI:63486 , ChemSpider:8325 , DrugBank:DB01667 , PubChem:8646

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -44.719

Enzymes inhibited by azaguanine, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: hypoxanthine transport [Papakostas13] , hypoxanthine transport [Papakostas13]

Inhibitor (Mechanism unknown) of: xanthine phosphoribosyltransferase [Deo85]


References

Deo85: Deo SS, Tseng WC, Saini R, Coles RS, Athwal RS (1985). "Purification and characterization of Escherichia coli xanthine-guanine phosphoribosyltransferase produced by plasmid pSV2gpt." Biochim Biophys Acta 839(3);233-9. PMID: 3886014

Papakostas13: Papakostas K, Botou M, Frillingos S (2013). "Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12." J Biol Chem 288(52);36827-40. PMID: 24214977


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc11.