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Escherichia coli K-12 substr. MG1655 Compound: cyanate

Synonyms: cyanic acid, hydrogen cyanate

Component of: CynR-Cyanate DNA-binding transcriptional activator (extended summary available)

Chemical Formula: CNO

Molecular Weight: 42.017 Daltons

Monoisotopic Molecular Weight: 43.0058136594 Daltons

SMILES: C([O-])#N

InChI: InChI=1S/CHNO/c2-1-3/h3H/p-1

InChIKey: InChIKey=XLJMAIOERFSOGZ-UHFFFAOYSA-M

Unification Links: CAS:420-05-3 , ChEBI:29195 , ChemSpider:10445868 , HMDB:HMDB02078 , IAF1260:37550 , KEGG:C01417 , MetaboLights:MTBLC29195 , PubChem:105034

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -23.28

Reactions known to consume the compound:

cyanate degradation :
cyanate + hydrogen carbonate + H+ → carbamate + CO2

In Reactions of unknown directionality:

Not in pathways:
CynR + cyanate = CynR-Cyanate

In Transport reactions:
cyanate[periplasmic space]cyanate[cytosol]

Enzymes inhibited by cyanate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: cyanase [Anderson86] , carbamoyl phosphate synthetase [Helmward89, Comment 1]

Inhibitor (Mechanism unknown) of: carbonic anhydrase [Guilloton92]

In Growth Media: Gutnick minimal salts medium base + cyanate

Transcription Units regulated by related protein CynR-Cyanate DNA-binding transcriptional activator (2 total):


References

Anderson75a: Anderson PM, Carlson JD (1975). "Reversible reaction of cyanate with a reactive sulfhydryl group at the glutamine binding site of carbamyl phosphate synthetase." Biochemistry 1975;14(16);3688-94. PMID: 240389

Anderson86: Anderson PM, Little RM (1986). "Kinetic properties of cyanase." Biochemistry 25(7);1621-6. PMID: 3518792

Guilloton92: Guilloton MB, Korte JJ, Lamblin AF, Fuchs JA, Anderson PM (1992). "Carbonic anhydrase in Escherichia coli. A product of the cyn operon." J Biol Chem 1992;267(6);3731-4. PMID: 1740425

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc14.