Escherichia coli K-12 substr. MG1655 Compound: cyanate

Synonyms: cyanic acid, hydrogen cyanate

Component of: CynR-Cyanate DNA-binding transcriptional activator (extended summary available)

Chemical Formula: CNO

Molecular Weight: 42.017 Daltons

Monoisotopic Molecular Weight: 43.0058136594 Daltons

cyanate compound structure


InChI: InChI=1S/CHNO/c2-1-3/h3H/p-1


Unification Links: CAS:420-05-3, ChEBI:29195, ChemSpider:10445868, HMDB:HMDB02078, IAF1260:37550, KEGG:C01417, MetaboLights:MTBLC29195, PubChem:105034

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -23.28

Reactions known to consume the compound:

cyanate degradation :
cyanate + hydrogen carbonate + H+ → carbamate + CO2

Not in pathways:
cyanate + hydrogen carbonate + 3 H+ → ammonium + 2 CO2

In Reactions of unknown directionality:

Not in pathways:
CynR + cyanate = CynR-Cyanate

In Transport reactions:

Enzymes inhibited by cyanate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: cyanase [Anderson86], carbamoyl phosphate synthetase [Helmward89, Comment 1] Inhibitor (Mechanism unknown) of: carbonic anhydrase [Guilloton92]

In Growth Media: Gutnick minimal salts medium base + cyanate

Transcription Units regulated by related protein CynR-Cyanate DNA-binding transcriptional activator (2 total):

Transcription-unit diagram

Transcription-unit diagram


Anderson75a: Anderson PM, Carlson JD (1975). "Reversible reaction of cyanate with a reactive sulfhydryl group at the glutamine binding site of carbamyl phosphate synthetase." Biochemistry 1975;14(16);3688-94. PMID: 240389

Anderson86: Anderson PM, Little RM (1986). "Kinetic properties of cyanase." Biochemistry 25(7);1621-6. PMID: 3518792

Guilloton92: Guilloton MB, Korte JJ, Lamblin AF, Fuchs JA, Anderson PM (1992). "Carbonic anhydrase in Escherichia coli. A product of the cyn operon." J Biol Chem 1992;267(6);3731-4. PMID: 1740425

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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