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Escherichia coli K-12 substr. MG1655 Compound: phenylmethanesulfonyl fluoride

Synonyms: PMSF

Chemical Formula: C7H7O2FS

Molecular Weight: 174.19 Daltons

Monoisotopic Molecular Weight: 174.01507835889998 Daltons

phenylmethanesulfonyl fluoride compound structure

SMILES: C(C1(C=CC=CC=1))S(=O)(F)=O

InChI: InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChIKey: InChIKey=YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Unification Links: ChEBI:8102, ChemSpider:4620, KEGG:C06747, PubChem:4784

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -32.38

Enzymes inhibited by phenylmethanesulfonyl fluoride, sorted by the type of inhibition, are:

Inhibitor (Irreversible) of: 1-phosphofructokinase [Buschmeier85] Inhibitor (Mechanism unknown) of: tail-specific protease [Park88], NADPH-dependent curcumin reductase [Hassaninasab11]

References

Buschmeier85: Buschmeier B, Hengstenberg W, Deutscher J (1985). "Purification and properties of 1-phosphofructokinase from Escherichia coli." FEMS Microbiol Lett 1985;29(3):231-235.

Hassaninasab11: Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M (2011). "Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism." Proc Natl Acad Sci U S A 108(16):6615-20. PMID: 21467222

Park88: Park JH, Lee YS, Chung CH, Goldberg AL (1988). "Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli." J Bacteriol 170(2);921-6. PMID: 2892828


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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