Escherichia coli K-12 substr. MG1655 Compound: Cd2+

Synonyms: Cadmium, Cd+2, Cd++

Superclasses: an iona cationan inorganic cationa divalent inorganic cation
an ionan inorganic ionan inorganic cationa divalent inorganic cation

Component of: dichlorocadmium

Chemical Formula: Cd

Molecular Weight: 112.4 Daltons

Monoisotopic Molecular Weight: 113.9033581 Daltons

SMILES: [Cd++]

InChI: InChI=1S/Cd/q+2


Unification Links: ChEBI:48775, ChemSpider:28935, HMDB:HMDB03638, IAF1260:1800088, KEGG:C01413, PubChem:31193

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

In Transport reactions:
Cd2+[cytosol] + H+[periplasm]Cd2+[periplasm] + H+[cytosol],
an ion[periplasm]an ion[extracellular space]

Enzymes activated by Cd2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: threonine dehydrogenase [Craig88a]

Enzymes inhibited by Cd2+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: fumarase A [Xu12], NADPH-dependent curcumin reductase [Hassaninasab11], acetylornithine deacetylase [JavidMajd00], D-arabinose isomerase [Boulter73], L-fucose isomerase [Boulter73], deoxyribose 1,5-phosphomutase [HammerJespersen70], glutamate decarboxylase B [Helmward89], 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80], ubiquinol oxidase (H+-transporting) [Kita84], 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [Ray80a], glutamate decarboxylase A [Helmward89], D-arabinose 5-phosphate isomerase [Meredith03, Lim66], N-acetylglutamate synthase [Marvil77], α-galactosidase [Burstein71], 2-amino-3-ketobutyrate CoA ligase [Mukherjee87]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: diacylglycerol kinase

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: methionine adenosyltransferase, adenylylsulfate kinase, NMN adenylyltransferase, carbamoyl phosphate synthetase

This compound has been characterized as an alternative substrate of the following enzymes: Zn2+:H+ antiporter, Zn2+-exporting ATPase


Boulter73: Boulter JR, Gielow WO (1973). "Properties of D-arabinose isomerase purified from two strains of Escherichia coli." J Bacteriol 113(2);687-96. PMID: 4632320

Burstein71: Burstein C, Kepes A (1971). "The alpha-galactosidase from Escherichia coli K12." Biochim Biophys Acta 1971;230(1);52-63. PMID: 5543331

Craig88a: Craig PA, Dekker EE (1988). "Cd2+ activation of L-threonine dehydrogenase from Escherichia coli K-12." Biochim Biophys Acta 1988;957(2);222-9. PMID: 3056527

HammerJespersen70: Hammer-Jespersen K, Munch-Petersen A (1970). "Phosphodeoxyribomutase from Escherichia coli. Purification and some properties." Eur J Biochem 1970;17(3);397-407. PMID: 4992818

Hassaninasab11: Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M (2011). "Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism." Proc Natl Acad Sci U S A 108(16):6615-20. PMID: 21467222

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

JavidMajd00: Javid-Majd F, Blanchard JS (2000). "Mechanistic analysis of the argE-encoded N-acetylornithine deacetylase." Biochemistry 2000;39(6);1285-93. PMID: 10684608

Kita84: Kita K, Konishi K, Anraku Y (1984). "Terminal oxidases of Escherichia coli aerobic respiratory chain. I. Purification and properties of cytochrome b562-o complex from cells in the early exponential phase of aerobic growth." J Biol Chem 1984;259(5);3368-74. PMID: 6365921

Lim66: Lim R, Cohen SS (1966). "D-phosphoarabinoisomerase and D-ribulokinase in Escherichia coli." J Biol Chem 1966;241(19);4304-15. PMID: 5332197

Marvil77: Marvil DK, Leisinger T (1977). "N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties." J Biol Chem 1977;252(10);3295-303. PMID: 16890

Meredith03: Meredith TC, Woodard RW (2003). "Escherichia coli YrbH is a D-arabinose 5-phosphate isomerase." J Biol Chem 278(35);32771-7. PMID: 12805358

Mukherjee87: Mukherjee JJ, Dekker EE (1987). "Purification, properties, and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme." J Biol Chem 1987;262(30);14441-7. PMID: 3117785

Ray80: Ray PH (1980). "Purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli." J Bacteriol 1980;141(2);635-44. PMID: 6988389

Ray80a: Ray PH, Benedict CD (1980). "Purification and characterization of specific 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Escherichia coli B." J Bacteriol 1980;142(1);60-8. PMID: 6246070

Xu12: Xu FF, Imlay JA (2012). "Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli." Appl Environ Microbiol 78(10);3614-21. PMID: 22344668

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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