Escherichia coli K-12 substr. MG1655 Compound Class: a siderophore

Superclasses: a secondary metabolite

Siderophores are small, high-affinity iron chelating compounds secreted by microorganisms. Once outside the cell, siderophores bind Fe3+ with high affinity, and the iron-siderophore complexes are imported back into the cell by active-transport mechanisms.

Siderophores are very common in pathogenic bacteria, since iron in the host organism is usually tightly bound to proteins, resulting in an extremely low concentration of free iron in the blood.

Most siderophores belong to one of three major groups: the catechols, hydroxamates and thiazolines.

Some grasses are known to make siderophores as well. These phytosiderophores are also known as mugineic acids.

a siderophore compound structure

Child Classes: a carboxylate siderophore (0) , a catecholate siderophore (1) , a hydroxamate siderophore (3) , a phytosiderophore (0) , a thiazoline siderophore (0) , an Fe(II)-siderophore (0) , an Fe(III)-siderophore (5)

SMILES: [a siderophoreH]

Unification Links: ChEBI:26672 , Wikipedia:Siderophore

Reactions known to consume the compound:

Not in pathways:
2 Fe2+ + 2 a siderophore + NADP+ + H+ ← 2 an Fe(III)-siderophore + NADPH

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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