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Escherichia coli K-12 substr. MG1655 Protein Class: a palmitoyl-[acp]

Synonyms: a palmitoyl-[acyl-carrier-protein]

Superclasses: a modified protein an acyl-protein thioester an acyl-[acyl-carrier protein] a fatty-acyl-[acp] a 2,3,4-saturated fatty acyl-[acp]
a modified protein an acyl-protein thioester an acyl-[acyl-carrier protein] a fatty-acyl-[acp] a long-chain acyl-[acp]
a modified protein an acyl-protein thioester an acyl-[acyl-carrier protein] a saturated acyl-[acp]
a modified protein an acyl-[acyl-carrier protein] a fatty-acyl-[acp] a 2,3,4-saturated fatty acyl-[acp]
a modified protein an acyl-[acyl-carrier protein] a fatty-acyl-[acp] a long-chain acyl-[acp]
a modified protein an acyl-[acyl-carrier protein] a saturated acyl-[acp]

SMILES: CCCCCCCCCCCCCCCC([a holo-[acyl-carrier protein]])=O

Unification Links: IAF1260:1437566

Reactions known to consume the compound:

palmitate biosynthesis II (bacteria and plants) :
a palmitoyl-[acp] + H2O → palmitate + a holo-[acyl-carrier protein] + H+

Not in pathways:
1-palmitoylglycerol 3-phosphate + a palmitoyl-[acp] → dipalmitoyl phosphatidate + a holo-[acyl-carrier protein]

fatty acid elongation -- saturated :
a malonyl-[acp] + a 2,3,4-saturated fatty acyl-[acp] + H+ → a holo-[acyl-carrier protein] + a 3-oxoacyl-[acp] + CO2

CDP-diacylglycerol biosynthesis II :
a 1-acyl-sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein] → a 1,2-diacyl-sn-glycerol 3-phosphate + a holo-[acyl-carrier protein]
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein] → a 1-acyl-sn-glycerol 3-phosphate + a holo-[acyl-carrier protein]

Reactions known to produce the compound:

palmitate biosynthesis II (bacteria and plants) :
a palmitoyl-[acp] + NAD+ ← a trans hexadecenoyl-[acp] + NADH + H+

fatty acid elongation -- saturated :
a 2,3,4-saturated fatty acyl-[acp] + NAD+ ← a trans-2-enoyl-[acyl-carrier protein] + NADH + H+
a 2,3,4-saturated fatty acyl-[acp] + NADP+ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H+

Not in pathways:
ATP + a holo-[acyl-carrier protein] + a fatty acid → AMP + a 2,3,4-saturated fatty acyl-[acp] + diphosphate

Reactions known to both consume and produce the compound:

Not in pathways:
an acyl-[acyl-carrier protein] + a 1-lyso-2-acyl-sn-glycero-3-phosphoethanolamine ↔ a holo-[acyl-carrier protein] + an L-1-phosphatidyl-ethanolamine

In Reactions of unknown directionality:

Not in pathways:
a 2,3,4-saturated 2-lysophosphatidate + a 2,3,4-saturated fatty acyl-[acp] = a 2,3,4-saturated L-phosphatidate + a holo-[acyl-carrier protein]


an acyl-[acyl-carrier protein] + NAD+ = a trans-2-enoyl-[acyl-carrier protein] + NADH + H+
an acyl-[acyl-carrier protein] + a malonyl-[acp] + H+ = a 3-oxoacyl-[acp] + CO2 + a holo-[acyl-carrier protein]

Enzymes inhibited by a palmitoyl-[acp], sorted by the type of inhibition, are:

Inhibitor (Competitive) of: β-ketoacyl-ACP synthase [Comment 1]

Inhibitor (Mechanism unknown) of: acetyl-CoA carboxyltransferase [Davis01] , 2,3,4-saturated fatty acyl-[acp]:NAD+ oxidoreductase [Heath95, Comment 2]

Inhibitor (Other types) of: β-ketoacyl-ACP synthase [Heath96, Comment 3]


References

Davis01: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Heath95: Heath RJ, Rock CO (1995). "Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli." J Biol Chem 270(44);26538-42. PMID: 7592873

Heath96: Heath RJ, Rock CO (1996). "Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli." J Biol Chem 1996;271(18);10996-1000. PMID: 8631920

Heath96a: Heath RJ, Rock CO (1996). "Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli." J Biol Chem 1996;271(4);1833-6. PMID: 8567624


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.