Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Protein Class: a non-ribosomal peptide synthetase

Summary:
The biosynthetic system for the production of a non-ribosomal peptide operates nucleic acid-free at the protein level. The specific condensation of amino acids and related carboxyl containing compounds is directed by protein templates, and each biosynthetic step generally requires a protein module. A minimal configuration consists of an adenylation domain for amino acid activation, a thiolation domain for transfer of activated intermediates, and a condensation domain.

Domains and modules are assembled at the gene level into gene clusters, which are translated into multifunctional proteins or multi-enzyme complexes, and post-translationally modified by addition of 4'-phosphopantetheine to the thiolation domain [Welker06].

Since a minimal module requires 3-3.5 kbp of genetic sequence, and since most non-ribosomal peptide synthetases (NRPSs) consist of several such modules, some NRPS genes are the largest known genes [Finking04].

Child Classes: a gramicidin-S synthetase (0) , a PchE NRPS protein (0) , a PchF NRPS protein (0)

Instances:
aryl-EntB

Gene-Reaction Schematic: ?

Credits:
Created 11-Sep-2008 by Caspi R , SRI International


References

Finking04: Finking R, Marahiel MA (2004). "Biosynthesis of nonribosomal peptides1." Annu Rev Microbiol 58;453-88. PMID: 15487945

Welker06: Welker M, von Dohren H (2006). "Cyanobacterial peptides - nature's own combinatorial biosynthesis." FEMS Microbiol Rev 30(4);530-63. PMID: 16774586


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.