Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Compound Class: NADHX

Superclasses: a redox electron carrier

Summary:
Studies in the 1950's have shown that glyceraldehyde 3-phosphate dehydrogenase slowly catalyzes the formation of NADHX from NADH [Rafter54]. The equilibrium of this hydration reaction is in favor (100/1) of the hydrated form [Acheson88], making the reaction virtually irreversible.

NADHX and NADPHX are inhibitors of several dehydrogenases [Prabhakar98] and it is thus important to eliminate them. Reconversion of NADHX to NADH is catalyzed by an ATP-dependent dehydratase [Yoshida75, Marbaix11].

Chemical Formula: C21H29N7O15P2

Instances:
(R)-NADHX ,
(S)-NADHX

Molecular Weight: 681.44 Daltons

Monoisotopic Molecular Weight: 683.1353363829999 Daltons

SMILES: C1(=C(CCC(O)N1C5(OC(COP(=O)([O-])OP(=O)([O-])OCC2(OC(C(O)C(O)2)N4(C=NC3(C(N)=NC=NC=34))))C(O)C(O)5))C(N)=O)

Credits:
Created 18-Oct-2011 by Keseler I , SRI International


References

Acheson88: Acheson SA, Kirkman HN, Wolfenden R (1988). "Equilibrium of 5,6-hydration of NADH and mechanism of ATP-dependent dehydration." Biochemistry 27(19);7371-5. PMID: 3061454

Marbaix11: Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL (2011). "Extremely Conserved ATP- or ADP-dependent Enzymatic System for Nicotinamide Nucleotide Repair." J Biol Chem 286(48);41246-52. PMID: 21994945

Prabhakar98: Prabhakar P, Laboy JI, Wang J, Budker T, Din ZZ, Chobanian M, Fahien LA (1998). "Effect of NADH-X on cytosolic glycerol-3-phosphate dehydrogenase." Arch Biochem Biophys 360(2);195-205. PMID: 9851831

Rafter54: Rafter, G. W., Chaykin, S., Krebs, E. G. (1954). "The action of glyceraldehyde-3-phosphate dehydrogenase on reduced diphosphopyridine nucleotide." J. Biol. Chem. 208: 799-812. PMID: 13174589

Yoshida75: Yoshida A, Dave V (1975). "Inhibition of NADP-dependent dehydrogenases by modified products of NADPH." Arch Biochem Biophys 169(1);298-303. PMID: 239637


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.