Escherichia coli K-12 substr. MG1655 Compound Class: an L-1-phosphatidyl-glycerol

Synonyms: 3-(3-sn-phosphatidyl)glycerol, 3(3-phosphatidyl-)glycerol, 1-phosphatidylglycerol, phosphatidylglycerol

Superclasses: a glycerophosphodiester
a lipida phospholipida phosphoglyceride

an L-1-phosphatidyl-glycerol compound structure

Child Classes: phosphatidylglycerol-32:0 (0), phosphatidylglycerol-32:1 (1), phosphatidylglycerol-34:0 (0), phosphatidylglycerol-34:1 (1), phosphatidylglycerol-34:2 (1), phosphatidylglycerol-34:3 (0), phosphatidylglycerol-34:4 (0)

phosphatidylglycerol (1,2-dicis-vaccenoyl),
phosphatidylglycerol (1-myristoyl, 2-cis-9,10-methylene hexadecanoyl),
phosphatidylglycerol (1-myristoyl, 2-palmitoleoyl),
phosphatidylglycerol (1-palmitoyl, 2-cis-9,10-methylene hexadecanoyl),
phosphatidylglycerol (1-palmitoyl, 2-lactobacilloyl),
phosphatidylglycerol (1-palmitoyl, 2-myristoyl),
phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1),
phosphatidylglycerol (dioctadecanoyl, n-C18:0)

SMILES: C(O)C(COP([O-])(=O)OCC(OC(=O)[R2])COC(=O)[R1])O

Unification Links: KEGG:C00344

Reactions known to consume the compound:

cardiolipin biosynthesis I :
2 an L-1-phosphatidyl-glycerol → a cardiolipin + glycerol

cardiolipin biosynthesis III :
an L-1-phosphatidyl-glycerol + an L-1-phosphatidylethanolamine → a cardiolipin + ethanolamine

Not in pathways:
an L-1-phosphatidyl-glycerol + ATP → an L-1-phosphatidylglycerol-phosphate + ADP + H+

glycerophosphodiester degradation :
a glycerophosphodiester + H2O → an alcohol + sn-glycerol 3-phosphate + H+

Reactions known to produce the compound:

cardiolipin biosynthesis I , cardiolipin biosynthesis III :
an L-1-phosphatidylglycerol-phosphate + H2O → an L-1-phosphatidyl-glycerol + phosphate

Reactions known to both consume and produce the compound:

Not in pathways:
an osmoregulated periplasmic glucan[periplasm] + an L-1-phosphatidyl-glycerol[periplasm] ↔ an osmoregulated periplasmic glucan with phosphoglycerol substituent[periplasm] + a 1,2-diacyl-sn-glycerol[periplasm] + H+[periplasm]

In Reactions of unknown directionality:

Not in pathways:
a prolipoprotein + an L-1-phosphatidyl-glycerol = a diacylglycerol prolipoprotein + sn-glycerol 1-phosphate

Not in pathways:
a diacylglycerol prolipoprotein[periplasm] + a phospholipid[periplasm] = murein lipoprotein[periplasm] + a lyso-phospholipid[periplasm]

In Transport reactions:
a glycerophosphodiester[periplasm] + ATP + H2O → a glycerophosphodiester[cytosol] + ADP + phosphate + H+

Enzymes activated by an L-1-phosphatidyl-glycerol, sorted by the type of activation, are:

Activator (Mechanism unknown) of: malate:quinone oxidoreductase [Narindrasorasak79], N-acetylmuramoyl-L-alanine amidase [Vanderwinkel85, Vanderwinkel87, Comment 1]

This compound has been characterized as an alternative substrate of the following enzymes: cyclopropane fatty acyl phospholipid synthase


Narindrasorasak79: Narindrasorasak S, Goldie AH, Sanwal BD (1979). "Characteristics and regulation of a phospholipid-activated malate oxidase from Escherichia coli." J Biol Chem 1979;254(5);1540-5. PMID: 368072

Vanderwinkel85: Vanderwinkel E, De Vlieghere M (1985). "Modulation of Escherichia coli N-acetylmuramoyl-L-alanine amidase activity by phosphatidylglycerol." Biochim Biophys Acta 1985;838(1);54-9. PMID: 2857097

Vanderwinkel87: Vanderwinkel E, de Vlieghere M, Charles P, Baptist V (1987). "Nature of the interactions involved in the lipid-protein complexes of the Escherichia coli N-acetylmuramoyl-L-alanine amidase." Biochim Biophys Acta 1987;913(2);238-44. PMID: 2885030

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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