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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0016829 - lyase activity

Definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Note that enzymes of class EC:4.99.-.- should also be annotated to this term.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0004325 - ferrochelatase activity (2),
GO:0016830 - carbon-carbon lyase activity (78),
GO:0016835 - carbon-oxygen lyase activity (78),
GO:0016840 - carbon-nitrogen lyase activity (16),
GO:0016846 - carbon-sulfur lyase activity (11),
GO:0016848 - carbon-halide lyase activity (2),
GO:0016849 - phosphorus-oxygen lyase activity (2),
GO:0018835 - carbon phosphorus lyase activity (1)

Term Members:
predicted pseudouridine 5'-phosphate glycosidase (psuG),
ureidoglycolate lyase (allA),
D-galactonate dehydratase (dgoD),
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA),
Fsa (fsaA),
2-methylisocitrate lyase (prpB),
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ),
2-methylcitrate dehydratase (prpD),
L-rhamnonate dehydratase (yfaW),
N-acetylmuramic acid 6-phosphate etherase (murQ),
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU),
D-cysteine desulfhydrase (dcyD),
predicted 2,3-dehydroadipyl-CoA hydratase (paaF),
glutamate decarboxylase B subunit (gadB),
glutamate decarboxylase A subunit (gadA),
2,3-diaminopropionate ammonia-lyase (ygeX),
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD),
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase monomer (ispF),
carbonic anhydrase 2 monomer (can),
lysine decarboxylase 2 (ldcC),
methylmalonyl-CoA decarboxylase (scpB),
4-hydroxy-2-ketovalerate aldolase (mhpE),
endonuclease VIII (nei),
S-ribosylhomocysteine lyase (luxS),
L-serine deaminase III (tdcG),
D-altronate dehydratase (uxaA),
galactarate dehydratase (garD),
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD),
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH),
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB),
fructose 6-phosphate aldolase 2 (fsaB),
rhamnulose-1-phosphate aldolase monomer (rhaD),
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF),
L-serine deaminase II (sdaB),
uroporphyrinogen decarboxylase (hemE),
o-succinylbenzoate synthase (menC),
Adi (adiA),
dTDP-glucose 4,6-dehydratase 2 (rffG),
chorismate lyase (ubiC),
aconitate hydratase 1 (acnA),
D-mannonate dehydratase (uxuA),
ferrochelatase (hemH),
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY),
phosphoenolpyruvate carboxykinase (ATP) (pck),
ornithine decarboxylase, biosynthetic (speC),
L-serine deaminase I (sdaA),
fumarase B monomer (fumB),
argininosuccinate lyase (argH),
3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein (ubiX),
oxalyl-CoA decarboxylase (oxc),
D-glucarate dehydratase (gudD),
glyoxylate carboligase (gcl),
phosphogluconate dehydratase (edd),
porphobilinogen synthase (hemB),
glyoxalase I (gloA),
fumarase A monomer,
dihydroneopterin aldolase (folB),
O-acetylserine sulfhydrylase A (cysK),
carbonic anhydrase monomer (cynT),
adenylosuccinate lyase (purB),
fructose bisphosphate aldolase monomer (fbaA),
3-octaprenyl-4-hydroxybenzoate carboxy-lyase monomer (ubiD),
isocitrate lyase monomer (aceA),
phosphatidylserine decarboxylase, proenzyme (psd),
tryptophan synthase, β subunit (trpB),
tryptophanase (tnaA),
3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB),
adenosylmethionine decarboxylase, proenzyme (speD),
methylglyoxal synthase (mgsA),
N-acetylneuraminate lyase (nanA),
4-hydroxy-tetrahydrodipicolinate synthase (dapA),
deoxyribose-phosphate aldolase (deoC),
3-dehydroquinate synthase (aroB),
formamidopyrimidine DNA glycosylase (mutM),
fumarase C monomer (fumC),
adenylate cyclase (cyaA),
threonine synthase (thrC),
D-serine ammonia-lyase (dsdA),
deoxyribodipyrimidine photolyase (photoreactivation) (phr),
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC),
anthranilate synthase component II (trpD),
anthranilate synthase component I (trpE),
cyanase monomer (cynS),
molybdopterin biosynthesis protein A (moaA),
Cys-tRNAPro and Cys-tRNACys deacylase (ybaK),
conserved protein (queE),
glyoxalase III, Hsp31 molecular chaperone (hchA),
lytic murein transglycosylase E (emtA),
tyrosine lyase (thiH),
carbon-phosphorus lyase core complex, PhnJ subunit,
HMP-P synthase (thiC),
membrane-bound lytic murein transglycosylase C (mltC),
membrane-bound lytic murein transglycosylase F (mltF),
soluble lytic murein transglycosylase (slt),
membrane-bound lytic murein transglycosylase D (mltD),
membrane-bound lytic murein transglycosylase B (mltB),
membrane-bound lytic murein transglycosylase A (mltA),
cysteine sulfinate desulfinase (csdA),
glucarate dehydratase-related protein (gudX),
CP4-6 prophage; D-xylonate dehydratase (yagF),
predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) (paaG),
L-cysteine desulfurase (sufS),
FadJ monomer,
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF),
citrate lyase, citrate-ACP transferase α subunit (citF),
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE),
imidazole glycerol phosphate synthase, HisF subunit,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH),
KpLE2 phage-like element; D-xylonate dehydratase (yjhG),
dTDP-glucose 4,6-dehydratase (rfbB),
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH),
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT),
crotonobetainyl-CoA hydratase (caiD),
ornithine decarboxylase, degradative (speF),
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB),
ethanolamine ammonia-lyase, β subunit (eutC),
ethanolamine ammonia-lyase, α subunit (eutB),
GDP-mannose 4,6-dehydratase (gmd),
L-tartrate dehydratase, β subunit (ttdB),
endonuclease III (nth),
citrate lyase, citryl-ACP lyase β subunit (citE),
fructose bisphosphate aldolase monomer (fbaB),
tryptophan synthase, α subunit (trpA),
PanD proenzyme, π protein,
uroporphyrinogen III synthase (hemD),
L-tartrate dehydratase, α subunit (ttdA),

Unification Links: GO:0016829

Relationship Links: ENZYME:RELATED-TO:4

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Jan 1, 2002, biocyc12.