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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0010629 - negative regulation of gene expression

Definition: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

Parent Classes:
GO:0010468 - regulation of gene expression ,
GO:0010605 - negative regulation of macromolecule metabolic process

Child Classes:
GO:0016458 - gene silencing (7) ,
GO:0017148 - negative regulation of translation (39) ,
GO:0045892 - negative regulation of transcription, DNA-templated (94)

Term Members:
PhoU ,
lipoyl(octanoyl) transferase (lipB) ,
IclR-pyruvate DNA-binding transcriptional repressor ,
GcvR-gly

Unification Links: GO:0010629


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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