Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0010629 - negative regulation of gene expression

Definition: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availabiliy of mRNA for translation and thereby reduces the rate of production of the encoded protein via translation.

Parent Classes:
GO:0010468 - regulation of gene expression,
GO:0010605 - negative regulation of macromolecule metabolic process

Child Classes:
GO:0016458 - gene silencing (7),
GO:0017148 - negative regulation of translation (40),
GO:0045892 - negative regulation of transcription, DNA-templated (114)

Term Members:
lipoyl(octanoyl) transferase (lipB),
IclR-pyruvate DNA-binding transcriptional repressor,

Unification Links: GO:0010629

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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