Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0009035 - Type I site-specific deoxyribonuclease activity

Synonyms: adenosine triphosphate-dependent deoxyribonuclease activity, ATP-dependent DNase activity, deoxyribonuclease (adenosine triphosphate-hydrolyzing), deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent), Type I restriction enzyme activity, type I site-specific deoxyribonuclease activity

Definition: Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.

Parent Classes:
GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters,
GO:0015666 - restriction endodeoxyribonuclease activity

Term Members:
host restriction; endonuclease R (hsdR)

Unification Links: GO:0009035

Relationship Links: ENZYME:RELATED-TO:, MetaCyc:RELATED-TO:

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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