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Escherichia coli K-12 substr. MG1655 Compound Class: D-fructuronate

Synonyms: fructuronate

Superclasses: an acid all carboxy acids a carboxylate

Chemical Formula: C6H9O7

Child Classes: D-fructofuranuronate (1)

Component of: UxuR-fructuronate

Citations: [Hickman60]

Molecular Weight: 193.13 Daltons

Monoisotopic Molecular Weight: 194.0426526757 Daltons

SMILES: C(=O)([O-])C(O)C(O)C(O)C(=O)CO

Unification Links: ChEBI:4126 , IAF1260:36345 , KEGG:C00905 , PubChem:439343

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -261.4 [Forsythe97]

Reactions known to produce the compound:

Not in pathways:
a carboxylic ester + H2O → an alcohol + a carboxylate + H+
an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+
an acyl phosphate + H2O → a carboxylate + phosphate + H+
an acyl-CoA + H2O → a carboxylate + coenzyme A + H+
a 1-lysophosphatidylcholine + H2O → a carboxylate + sn-glycero-3-phosphocholine + H+

Reactions known to both consume and produce the compound:

β-D-glucuronide and D-glucuronate degradation :
aldehydo-D-glucuronate ↔ D-fructuronate

D-fructuronate degradation :
D-mannonate + NAD+D-fructuronate + NADH + H+

In Reactions of unknown directionality:

Not in pathways:
D-fructuronate + UxuR = UxuR-fructuronate


an aldehyde[periplasmic space] + FAD[periplasmic space] + H2O[periplasmic space] = a carboxylate[periplasmic space] + FADH2[periplasmic space]

In Transport reactions:
D-fructuronate[periplasmic space] + H+[periplasmic space]D-fructuronate[cytosol] + H+[cytosol]

Enzymes inhibited by D-fructuronate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: altronate oxidoreductase [Portalier72b, Comment 1]


References

Forsythe97: Forsythe RG, Karp PD, Mavrovouniotis ML (1997). "Estimation of Equilibrium Constants Using Automated Group Contribution Methods." CABIOS 13(5):537-543.

Hickman60: Hickman, J., Ashwell, G. (1960). "Uronic Acid Metabolism in Bacteria: II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli." J. Biol. Chem. 235:1566-1570.

Portalier72a: Portalier RC, Stoeber FR (1972). "[D-altronate: NAD-oxidoreductase in Escherichia coli K12. Purification, properties, and specificity]." Eur J Biochem 1972;26(1);50-61. PMID: 4402917

Portalier72b: Portalier RC (1972). "[D-altronate: NAD-oxidoreductase from Escherichia coli K12. Kinetic studies]." Eur J Biochem 1972;30(2);211-9. PMID: 4351434


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, BIOCYC14B.