Current and Filled Pathway Holes of <i>Aquifex aeolicus</i> VF5

Current and Filled Pathway Holes of Aquifex aeolicus VF5

A pathway hole is a pathway reaction for which no corresponding enzyme has been identified in the genome. We consider only contiguous pathways (pathways containing connected sets of reactions, as opposed to pathways containing unconnected sets of reactions) when enumerating pathway holes.

This report includes two tables regarding pathway holes in Aquifex aeolicus VF5:

Current Pathway Holes: A list of reactions within metabolic pathways of Aquifex aeolicus VF5 for which no corresponding enzyme has been found.

Filled Pathway Holes: A list of former pathway holes within metabolic pathways of Aquifex aeolicus VF5 which have been filled with the assistance of the Pathway Hole Filler.




Current Pathway Holes

This table lists reactions within metabolic pathways of Aquifex aeolicus VF5 for which no corresponding enzyme has been identified in the genome. The presence of those enzymes is suggested by the presence of the pathway.

101 pathway holes (20.3%) are present in the 498 total reactions of 127 pathways

Reaction EC# Pathway(s) needing this reaction
L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2O → L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine 3.4.17.13 anhydromuropeptides recycling
N-acetyl-D-glucosamine 6-phosphate + H2O → D-glucosamine 6-phosphate + acetate 3.5.1.25 anhydromuropeptides recycling
N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + H2O → N-acetyl-β-D-glucosamine + 1,6-anhydro-N-acetyl-β-muramate 3.2.1.52 anhydromuropeptides recycling
1,6-anhydro-N-acetyl-β-muramate + ATP + H2O → N-acetyl-β-muramate 6-phosphate + ADP + H+ 2.7.1.170 anhydromuropeptides recycling
N-acetyl-β-muramate 6-phosphate + H2O → N-acetyl-D-glucosamine 6-phosphate + (R)-lactate 4.2.1.126 anhydromuropeptides recycling
acetate + ATP + coenzyme A → acetyl-CoA + AMP + diphosphate 6.2.1.1 ethanol degradation II
hydrogen carbonate + H+ ← CO2 + H2O 4.2.1.1 cyanate degradation
N-acetyl-L-ornithine + H2O → L-ornithine + acetate 3.5.1.16 ornithine biosynthesis
2 hydrogen peroxide → 2 H2O + oxygen 1.11.1.6/1.11.1.21 superoxide radicals degradation
GMP + ATP → GDP + ADP 2.7.4.8 guanosine ribonucleotides de novo biosynthesis
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O → 5-amino-6-(D-ribitylamino)uracil + phosphate [none] flavin biosynthesis I (bacteria and plants)
an [L-2-aminoadipate carrier protein]-L-ornithine + H2O → L-ornithine + a [LysW protein]-L-glutamate 3.5.1.- arginine biosynthesis IV (archaebacteria)
L-glutamate + a [LysW protein]-L-glutamate + ATP → an [L-2-aminoadipate carrier protein]-L-glutamate + ADP + phosphate + H+ 6.3.2.- arginine biosynthesis IV (archaebacteria)
a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + a [lipoyl-carrier protein] → a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + [glycine cleavage system lipoyl-carrier protein]-L-lysine 2.3.1.200 lipoate salvage II
a long-chain acyl-CoA + a 1-acyl-sn-glycerol 3-phosphate → a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A 2.3.1.51 CDP-diacylglycerol biosynthesis I
ammonium + CO2 + ATP ← carbamoyl-phosphate + ADP + 2 H+ 2.7.2.2 citrulline degradation
L-tyrosine + S-adenosyl-L-methionine + an reduced unknown electron acceptor → 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + an oxidized unknown electron acceptor + 2 H+ 4.1.99.19 thiazole biosynthesis I (E. coli)
a stearoyl-[acp] + H2O → stearate + a holo-[acyl-carrier protein] + H+ 3.1.2.14 stearate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxystearoyl-[acp] → a trans-octadec-2-enoyl-[acp] + H2O 2.3.1.86/4.2.1.59 stearate biosynthesis II (bacteria and plants)
L-threonine → (2Z)-2-aminobut-2-enoate + H2O + H+ [none] isoleucine biosynthesis I (from threonine)
tetrahydrobiopterin + NAD+ ← 7,8-dihydrobiopterin + NADH + H+ 1.5.1.- phenylalanine degradation I (aerobic)
tetrahydrobiopterin + L-phenylalanine + oxygen → L-tyrosine + 4α-hydroxy-tetrahydrobiopterin 1.14.16.1 phenylalanine degradation I (aerobic)
5,10-methylenetetrahydrofolate + NAD+ → 5,10-methenyltetrahydrofolate + NADH 1.5.1.15 folate transformations I
trimethyl sulfonium + tetrahydrofolate ← dimethyl sulfide + 5-methyl-tetrahydrofolate + H+ 2.1.1.19 folate transformations I
L-homocysteine + 5-methyl-tetrahydrofolate → L-methionine + tetrahydrofolate 2.1.1.13 formylTHF biosynthesis, folate transformations I
pppGpp + H2O → ppGpp + phosphate + H+ 3.6.1.40 ppGpp biosynthesis
a palmitoleoyl-[acp] + H2O → palmitoleate + a holo-[acyl-carrier protein] + H+ 3.1.2.14 palmitoleate biosynthesis I
selenodiglutathione + NADPH → glutathioselenol + glutathione + NADP+ [none] selenate reduction
glutathioselenol + NADPH + 2 H+ → hydrogen selenide + glutathione + NADP+ [none] selenate reduction
selenite + AMP + glutathione disulfide + 3 H+ ← adenosine 5'-phosphoselenate + 2 glutathione 1.8.4.9 selenate reduction
2-oxo-3-hydroxy-4-phosphobutanoate + L-glutamate → 4-phospho-hydroxy-L-threonine + 2-oxoglutarate 2.6.1.52 pyridoxal 5'-phosphate biosynthesis I
pyridoxine 5'-phosphate + oxygen → hydrogen peroxide + pyridoxal 5'-phosphate 1.4.3.5 pyridoxal 5'-phosphate biosynthesis I
S-adenosyl-L-methionine + a demethylated methyl donor → S-adenosyl-L-homocysteine + a methylated methyl donor 2.1.1.- methionine degradation I (to homocysteine), S-adenosyl-L-methionine cycle II
succinate[in] + a ubiquinone[membrane] → fumarate[in] + an ubiquinol[membrane] 1.3.5.1 TCA cycle I (prokaryotic), aerobic respiration (cytochrome c)
2 an oxidized c-type cytochrome[membrane] + an ubiquinol[membrane] → 2 a reduced c-type cytochrome[membrane] + a ubiquinone[membrane] 1.10.2.2 aerobic respiration (cytochrome c)
protoporphyrinogen IX[membrane] + 3 a menaquinone[membrane] → protoporphyrin IX[membrane] + 3 a menaquinol[membrane] 1.3.5.3 heme biosynthesis from uroporphyrinogen-III II (anaerobic)
ATP + acetate ← ADP + acetyl phosphate 2.7.2.1 mixed acid fermentation
acetyl-CoA + phosphate → acetyl phosphate + coenzyme A 2.3.1.8 mixed acid fermentation
pyruvate + L-valine → L-alanine + 3-methyl-2-oxobutanoate 2.6.1.66 alanine biosynthesis I
a α-limit dextrin with short branches + H2O → a debranched α-limit dextrin + β-D-glucose 3.2.1.33 glycogen degradation II
an epoxyqueuosine34 in tRNA → a queuosine34 in tRNA [none] queuosine biosynthesis
a guanine34 in tRNA + preQ1 → a 7-aminomethyl-7-deazaguanosine34 in tRNA + guanine 2.4.2.29 queuosine biosynthesis
maltotriose + H2O → maltose + D-glucopyranose 3.2.1.20 glycogen degradation I
an α-limit dextrin + H2O → maltotetraose + a debranched α-limit dextrin 3.2.1.33 glycogen degradation I
(R)-3-hydroxy-cis-vacc-11-enoyl-[acp] → a (2-trans-11-cis)-vaccen-2-enoyl-[acp] + H2O 4.2.1.59 cis-vaccenate biosynthesis
a cis-vaccenoyl-[acp] + H2O → cis-vaccenate + a holo-[acyl-carrier protein] + H+ 3.1.2.14 cis-vaccenate biosynthesis
isopentenyl diphosphate ↔ dimethylallyl diphosphate 5.3.3.2 methylerythritol phosphate pathway
3-phospho-L-serine + H2O → L-serine + phosphate 3.1.3.3 serine biosynthesis
3-phospho-L-serine + 2-oxoglutarate ← L-glutamate + 3-phospho-hydroxypyruvate 2.6.1.52 serine biosynthesis
guanosine + H2O → D-ribofuranose + guanine 3.2.2.1 guanine and guanosine salvage II
formate + acetyl-CoA ← pyruvate + coenzyme A 2.3.1.54 mixed acid fermentation, respiration (anaerobic)
oxaloacetate + phosphate ← phosphoenolpyruvate + hydrogen carbonate 4.1.1.31 mixed acid fermentation, respiration (anaerobic)
pyruvate + ATP ↔ phosphoenolpyruvate + ADP + H+ 2.7.1.40 mixed acid fermentation, respiration (anaerobic)
6-phospho D-glucono-1,5-lactone + H2O → D-gluconate 6-phosphate + H+ 3.1.1.31 pentose phosphate pathway (oxidative branch) I
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O → 3-deoxy-D-arabino-heptulosonate-7-phosphate + phosphate 2.5.1.54 3-dehydroquinate biosynthesis I
creatinine + H+ + H2O → ammonium + N-methylhydantoin 3.5.4.21 creatinine degradation II
sarcosine + oxygen + H2O → glycine + formaldehyde + hydrogen peroxide 1.5.3.1 creatinine degradation II
sarcosine + an oxidized electron-transfer flavoprotein + H2O → glycine + formaldehyde + a reduced electron-transfer flavoprotein 1.5.8.3 creatinine degradation II
N-carbamoylsarcosine + 2 H+ + H2O → ammonium + CO2 + sarcosine 3.5.1.59 creatinine degradation II
α-D-ribose-1-phosphate → D-ribose 5-phosphate 5.4.2.7 purine ribonucleosides degradation
adenosine + H+ + H2O → ammonium + inosine 3.5.4.4 adenine and adenosine salvage III, purine ribonucleosides degradation
a polycistronic tRNA precursor + H2O → a tRNA precursor with a 5' extension and a short 3' extension + a partially processed polycistronic tRNA precursor 3.1.26.12 tRNA processing
a tRNA precursor with a 5' extension and a short 3' extension → a tRNA precursor with a 5' extension + a ribonucleoside 5'-monophosphate 3.1.13.5 tRNA processing
a tRNA precursor with a 5' extension and a short 3' extension + H2O → a tRNA precursor with a short 3' extension + a single-stranded RNA 3.1.26.5 tRNA processing
a tRNA precursor with a short 3' extension → an uncharged tRNA + n a nucleoside 5'-monophosphate 3.1.13.5 tRNA processing
a tRNA precursor with a 5' extension + H2O → an uncharged tRNA + a single-stranded RNA 3.1.26.5 tRNA processing
a tRNA precursor with a 5' extension and a long 3' trailer + H2O → a tRNA precursor with a 5' extension + a ribonucleoside 5'-monophosphate 3.1.13.1 tRNA processing
a polycistronic tRNA precursor + H2O → a tRNA precursor with a 5' extension and a long 3' trailer + a partially processed polycistronic tRNA precursor 3.1.26.12 tRNA processing
xanthine + NAD+ + H2O → urate + NADH + H+ 1.17.1.4 urate biosynthesis/inosine 5'-phosphate degradation
L-tyrosine + 2-oxoglutarate ← 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.5/2.6.1.57 tyrosine biosynthesis I
a dodecanoyl-[acp] + H2O → a holo-[acyl-carrier protein] + laurate + H+ 3.1.2.21 palmitate biosynthesis II (bacteria and plants)
a palmitoyl-[acp] + H2O → palmitate + a holo-[acyl-carrier protein] + H+ 3.1.2.14 palmitate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxypalmitoyl-[acp] → a trans hexadecenoyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxydodecanoyl-[acp] → a (2E)-dodec-2-enoyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxyoctanoyl-[acp] → a trans oct-2-enoyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxybutanoyl-[acp] → a crotonyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants)
a (3R)-3-hydroxyhexanoyl-[acp] → a trans hex-2-enoyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants)
dUMP + 5,10-methylenetetrahydrofolate → dTMP + 7,8-dihydrofolate 2.1.1.45 pyrimidine deoxyribonucleotides de novo biosynthesis II, formylTHF biosynthesis
XMP + diphosphate ← xanthine + 5-phospho-α-D-ribose 1-diphosphate 2.4.2.22 xanthine and xanthosine salvage
(R)-pantothenate + ATP → D-4'-phosphopantothenate + ADP + H+ 2.7.1.33 phosphopantothenate biosynthesis I
β-nicotinamide D-ribonucleotide + H2O → D-ribofuranose 5-phosphate + nicotinamide + H+ 3.2.2.14 NAD salvage pathway I
NAD+ + H2O → β-nicotinamide D-ribonucleotide + AMP + 2 H+ 3.6.1.22 NAD salvage pathway I
a (3R)-3-hydroxydecanoyl-[acp] → a (2E)-dec-2-enoyl-[acp] + H2O 2.3.1.85/2.3.1.86/4.2.1.59 palmitate biosynthesis II (bacteria and plants), cis-dodecenoyl biosynthesis
a (2E)-dec-2-enoyl-[acp] → a (3Z)-dec-3-enoyl-[acp] 5.3.3.14 cis-dodecenoyl biosynthesis
AMP + diphosphate ← adenine + 5-phospho-α-D-ribose 1-diphosphate 2.4.2.7 adenine and adenosine salvage I
ammonia[membrane] + 6 an oxidized c-type cytochrome[membrane] + 2 H2O[membrane] ← nitrite[membrane] + 6 a reduced c-type cytochrome[membrane] + 7 H+[membrane] 1.7.2.2 nitrate reduction IV (dissimilatory)
2'-deoxyadenosine + H+ + H2O → ammonium + 2'-deoxyinosine 3.5.4.4 purine deoxyribonucleosides degradation
an oxidized thioredoxin + 2 e- = a reduced thioredoxin [none] thioredoxin pathway
ATP + 4-methyl-5-(β-hydroxyethyl)thiazole → ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole + H+ 2.7.1.50 4-methyl-5(beta-hydroxyethyl)thiazole salvage (yeast)
carbon monoxide + an oxidized ferredoxin [iron-sulfur] cluster + H2O ← CO2 + a reduced ferredoxin [iron-sulfur] cluster + H+ 1.2.7.4 reductive acetyl coenzyme A pathway
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] ← carbon monoxide + a [methyl-Co(III) corrinoid Fe-S protein] + coenzyme A 2.3.1.169 reductive acetyl coenzyme A pathway
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate ← a [Co(I) corrinoid Fe-S protein] + 5-methyl-tetrahydrofolate 2.1.1.258 reductive acetyl coenzyme A pathway
oxaloacetate + ATP → CO2 + phosphoenolpyruvate + ADP 4.1.1.49 gluconeogenesis I
fructose 1,6-bisphosphate + H2O → β-D-fructofuranose 6-phosphate + phosphate 3.1.3.11 gluconeogenesis I
β-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate 5.3.1.9 gluconeogenesis I, UDP-N-acetyl-D-glucosamine biosynthesis I, GDP-mannose biosynthesis
a (3R)-3-hydroxymyristoyl-[acp] + UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine → UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-α-D-glucosamine + a holo-[acyl-carrier protein] + H+ 2.3.1.191 lipid IVA biosynthesis
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-α-D-glucosamine + H2O → 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate + UMP + 2 H+ 3.6.1.54 lipid IVA biosynthesis
an octanoyl-[acp] + a [lipoyl-carrier protein] → a [lipoyl-carrier protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H+ 2.3.1.181 lipoate biosynthesis and incorporation I
D-glucopyranose 6-phosphate → 1D-myo-inositol 3-monophosphate 5.5.1.4 myo-inositol biosynthesis
tetrahydrofolate + NADP+ ← 7,8-dihydrofolate + NADPH + H+ 1.5.1.3 formylTHF biosynthesis, tetrahydrofolate biosynthesis
ATP + 2-oxoglutarate + CO2 + H2O → oxalosuccinate + ADP + phosphate + 2 H+ 6.4.1.7 reductive TCA cycle II



Filled Pathway Holes

Key:
Hole-filler The gene whose product is predicted to catalyze the missing reaction.
Hole EC# The EC number of the missing reaction (links to the reaction page).
P(has-function) The probability that the hole-filler catalyzes the missing reaction as determined by the PHFiller.
All functions of hole-filler All current annotations of the hole-filler, including the function of the missing reaction to which it has been assigned.
Pathway(s) requiring this reaction All metabolic pathways in which the pathway hole occurs in the database.

04:33:32 of Wednesday, 7/27/2016 (GMT-8)

65 pathway holes have been filled by the pathway hole filler, in 127 pathways.

Hole-filler Hole EC# P(has-function) All functions of hole-filler Pathway(s) requiring this reaction
xylR 2.7.1.2 0.975 NagC/XylR family transcriptional regulator glycogen degradation I
ribD1 1.1.1.193 0.999 riboflavin specific deaminase flavin biosynthesis I (bacteria and plants)
ribF 2.7.7.2 0.999 riboflavin kinase flavin biosynthesis I (bacteria and plants)
gltA 4.1.3.34 0.996 citrate synthase reductive TCA cycle II
aq_1656 2.7.1.130 0.975 hypothetical protein lipid IVA biosynthesis
aspS 6.1.1.- 0.917 aspartyl-tRNA synthetase asparagine biosynthesis III (tRNA-dependent)
fabF 2.3.1.179 0.996 3-oxoacyl-ACP synthase cis-vaccenate biosynthesis
aq_1727 1.1.1.169 0.975 hypothetical protein phosphopantothenate biosynthesis I
aq_1731 6.3.3.2 0.975 hypothetical protein folate transformations I, formylTHF biosynthesis
proC 1.5.1.2 0.991 pyrroline carboxylate reductase proline biosynthesis I
folD 6.3.4.3 1.000 methylenetetrahydrofolate dehydrogenase folate polyglutamylation, folate transformations I, reductive acetyl coenzyme A pathway
folD 3.5.4.9 1.000 methylenetetrahydrofolate dehydrogenase tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate, folate transformations I, formylTHF biosynthesis, reductive acetyl coenzyme A pathway
gcsP1 2.1.2.10 0.992 glycine dehydrogenase subunit 2 glycine cleavage, GCVMULTI-RXN
serA 1.1.1.290 0.978 D-3-phosphoglycerate dehydrogenase pyridoxal 5'-phosphate biosynthesis I
umpS 2.4.2.10 0.966 uridine 5-monophosphate synthase UMP biosynthesis
thiD 2.7.1.49 1.000 HMP-P kinase hydroxymethylpyrimidine salvage
hisIE 3.6.1.31 0.999 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP histidine biosynthesis
aspC1 2.6.1.88 0.991 aspartate aminotransferase S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I
masA 5.3.2.5 0.993 enolase-phosphatase E-1 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I
masA 3.1.3.87 0.993 enolase-phosphatase E-1 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I
imp2 3.1.3.15 0.917 myo-inositol-1(or 4)-monophosphatase histidine biosynthesis
aq_1996 3.5.1.42 0.978 hypothetical protein NAD salvage pathway I
eif 5.3.1.23 0.991 initiation factor eIF-2B subunit alpha S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I
narB none 0.992 nitrate reductase narB respiration (anaerobic), mixed acid fermentation
phpA 3.1.13.1 0.995 polynucleotide phosphorylase/polyadenylase tRNA processing
purK 6.3.4.18 0.991 phosphoribosylaminoimidazole carboxylase ATPase subunit inosine-5'-phosphate biosynthesis I
gatA 3.5.1.- 0.917 aspartyl/glutamyl-tRNA amidotransferase subunit A lipoate salvage II
ribA 4.1.99.12 1.000 GTP cyclohydrolase II flavin biosynthesis I (bacteria and plants)
aq_036 2.7.7.18 0.975 hypothetical protein NAD salvage pathway I, NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD biosynthesis I (from aspartate)
ilvB 4.1.1.72 0.998 acetolactate synthase large subunit valine degradation II
pmu 5.4.2.10 0.995 phosphoglucomutase/phosphomannomutase anhydromuropeptides recycling, UDP-N-acetyl-D-glucosamine biosynthesis I
pmu 5.4.2.7 0.975 phosphoglucomutase/phosphomannomutase 2'-deoxy-alpha-D-ribose 1-phosphate degradation
pyrD 1.3.5.2 0.994 dihydroorotate dehydrogenase 1B UMP biosynthesis
xanB 2.7.7.13 0.999 mannose-6-phosphate isomerase/mannose-1-phosphate guanyl transferase GDP-mannose biosynthesis
fabZ 4.2.1.59 0.990 (3R)-hydroxymyristoyl-ACP dehydratase cis-dodecenoyl biosynthesis
fabZ 4.2.1.59 0.990 (3R)-hydroxymyristoyl-ACP dehydratase palmitoleate biosynthesis I
fabZ 4.2.1.59 0.990 (3R)-hydroxymyristoyl-ACP dehydratase palmitoleate biosynthesis I
fabZ 2.3.1.85/2.3.1.86/4.2.1.59 0.996 (3R)-hydroxymyristoyl-ACP dehydratase fatty acid elongation -- saturated
glmU 2.3.1.157 0.999 UDP-N-acetylglucosamine pyrophosphorylase anhydromuropeptides recycling, UDP-N-acetyl-D-glucosamine biosynthesis I
aq_707 none 0.975 hypothetical protein thiazole biosynthesis II (Bacillus)
mpg 2.7.7.27 0.997 mannose-1-phosphate guanyltransferase glycogen biosynthesis I (from ADP-D-Glucose)
lpdA none 0.993 dihydrolipoamide dehydrogenase folate transformations I, formylTHF biosynthesis
lpdA 1.2.1.- 0.993 dihydrolipoamide dehydrogenase respiration (anaerobic)
nifS2 none 0.993 FeS cluster formation protein NifS thiazole biosynthesis II (Bacillus)
nifS2 none 1.000 FeS cluster formation protein NifS thiazole biosynthesis I (E. coli)
nifS2 2.8.1.7 1.000 FeS cluster formation protein NifS thiazole biosynthesis II (Bacillus), thiazole biosynthesis I (E. coli)
murF 6.3.2.10 0.998 UDP-MurNAc-pentapeptide sythetase UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing)
surE 3.1.3.5 0.993 stationary phase survival protein SurE urate biosynthesis/inosine 5'-phosphate degradation
spoT 3.1.7.2 0.996 (p)ppGpp 3-pyrophosphohydrolase ppGpp biosynthesis
spoT 2.7.6.5 0.997 (p)ppGpp 3-pyrophosphohydrolase ppGpp biosynthesis
spoT 2.7.6.5 0.999 (p)ppGpp 3-pyrophosphohydrolase ppGpp biosynthesis
aroE 1.1.1.282 0.998 shikimate 5-dehydrogenase chorismate biosynthesis from 3-dehydroquinate
aq_957 4.6.1.12 0.998 hypothetical protein methylerythritol phosphate pathway
gap 1.2.1.72 0.992 glyceraldehyde-3-phosphate dehydrogenase pyridoxal 5'-phosphate biosynthesis I
forA2 1.2.7.1 0.939 ferredoxin oxidoreductase subunit alpha reductive TCA cycle II, gluconeogenesis II (Methanobacterium thermoautotrophicum)
purE 5.4.99.18 0.990 phosphoribosylaminoimidazole carboxylase inosine-5'-phosphate biosynthesis I
forB1 1.2.7.3 0.979 ferredoxin oxidoreductase subunit beta reductive TCA cycle II
thiC 4.1.99.17 0.987 thiamine biosynthesis protein ThiC 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis
gltX none 0.996 glutamyl-tRNA synthetase L-glutamine biosynthesis II (tRNA-dependent)
sucC1 6.2.1.18 0.999 succinyl-CoA ligase subunit beta reductive TCA cycle II
moeB none 0.998 molybdopterin biosynthesis protein MoeB thiazole biosynthesis I (E. coli)
moeB 2.7.7.73 0.998 molybdopterin biosynthesis protein MoeB thiazole biosynthesis II (Bacillus), thiazole biosynthesis I (E. coli)
murC 6.3.2.- 0.991 UDP-N-acetylmuramate-alanine ligase anhydromuropeptides recycling
thiE1 5.3.99.10 0.975 thiamine phosphate synthase thiazole biosynthesis II (Bacillus)


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