Aquifex aeolicus VF5 Pathway: inosine-5'-phosphate biosynthesis II
Inferred by computational analysis

Pathway diagram: inosine-5'-phosphate biosynthesis II

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Synonyms: IMP biosynthesis II

Superclasses: BiosynthesisNucleosides and Nucleotides BiosynthesisPurine Nucleotide BiosynthesisPurine Nucleotides De Novo BiosynthesisPurine Riboucleotides De Novo BiosynthesisInosine-5'-phosphate Biosynthesis

Pathway Summary from MetaCyc:
De novo biosynthesis of purines starts with the synthesis of IMP, which can be converted to all other purines.

In the bacterium Escherichia coli IMP is synthesized from 5-amino-1-(5-phospho-β-D-ribosyl)imidazole in 6 steps (see inosine-5'-phosphate biosynthesis I). In eukaryotes the pathway consists of only 5 steps. The difference is in the first two steps, which are replaced in eukaryotes with a single reaction.

The first 3 steps of this pathway are catalyzed in the yeast Saccharomyces cerevisiae by individual enzymes, while the last two steps are catalyzed by a single multifunctional enzyme|. Saccharomyces cerevisiae possesses two isozymes of the multifunctional enzyme, encoded by the ADE16 and ADE17 genes. While these isozymes are indistinguishable with respect to activity, cellular location and subunit structure, they do differ in expression levels, and Ade17 is the major isozyme, accounting for approximately 90% activity [Tibbetts00, Tibbetts97].

Superpathways: superpathway of purine nucleotides de novo biosynthesis I

Variants: inosine-5'-phosphate biosynthesis I

Pathway Evidence Glyph:

Pathway evidence glyph

This organism is not in the expected taxonomic range for this pathway.

Key to pathway glyph edge colors:

  An enzyme catalyzing this reaction is present in this organism
  The reaction is unique to this pathway in MetaCyc

Created in MetaCyc 13-Jan-2009 by Caspi R, SRI International
Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Tibbetts00: Tibbetts AS, Appling DR (2000). "Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae." J Biol Chem 2000;275(27);20920-7. PMID: 10877846

Tibbetts97: Tibbetts AS, Appling DR (1997). "Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase." Arch Biochem Biophys 1997;340(2);195-200. PMID: 9143321

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Hanson02: Hanson AD, Gregory JF (2002). "Synthesis and turnover of folates in plants." Curr Opin Plant Biol 5(3);244-9. PMID: 11960743

Jabrin03: Jabrin S, Ravanel S, Gambonnet B, Douce R, Rebeille F (2003). "One-carbon metabolism in plants. Regulation of tetrahydrofolate synthesis during germination and seedling development." Plant Physiol 131(3);1431-9. PMID: 12644692

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lucock00: Lucock M (2000). "Folic acid: nutritional biochemistry, molecular biology, and role in disease processes." Mol Genet Metab 71(1-2);121-38. PMID: 11001804

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